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Collaborative Research and Development Agreements - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Nov. 30, 2016 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Dec. 31, 2016 | Sep. 30, 2017
Deferred Revenue Arrangement [Line Items] |  |  |  |  |  |
Liability related to unused development funding |  |  | $ 11,192,000 |  | $ 11,192,000 | $ 7,567,000
Maximum |  |  |  |  |  |
Deferred Revenue Arrangement [Line Items] |  |  |  |  |  |
Additional milestone payments eligible to be received based on achievement of certain development and regulatory objectives |  |  |  |  |  | 100,000,000
Astra Zeneca |  |  |  |  |  |
Deferred Revenue Arrangement [Line Items] |  |  |  |  |  |
Additional collaboration revenue |  |  |  |  | 800,000 |
Milestone payments earned | $ 7,200,000 |  |  |  |  |
Unused development funding advanced by AstraZeneca | $ 7,400,000 |  |  |  |  |
Milestone revenue recognition |  |  | 7,200,000 | $ 104,000 |  |
Unused development funding paid |  | $ 200,000 |  |  |  |
Liability related to unused development funding |  |  |  |  |  | 0
Deferred revenue |  |  | $ 0 |  | $ 0 | $ 0

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