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Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
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Sep. 30, 2017 | Sep. 30, 2016 | Sep. 30, 2017 | Sep. 30, 2016
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |  |  |
Stock-based compensation expense | $ 3,660 | $ 3,661 | $ 10,844 | $ 10,030
Research and Development |  |  |  |
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |  |  |
Stock-based compensation expense | 1,973 | 1,639 | 5,707 | 4,490
General and Administrative |  |  |  |
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |  |  |
Stock-based compensation expense | $ 1,687 | $ 2,022 | $ 5,137 | $ 5,540

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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