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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Collaboration revenue				$ 2,578
Grant revenue	$ 53	$ 162	$ 306	289
Service and license revenue				884
Total revenues	53	162	306	3,751
Operating expenses:
Research and development	16,417	23,234	47,576	66,051
General and administrative	6,027	11,766	18,111	29,086
Restructuring			2,783
Total operating expenses	22,444	35,000	68,470	95,137
Loss from operations	(22,391)	(34,838)	(68,164)	(91,386)
Other income (expense):
Interest income	429	170	809	615
Other (expense) income, net	(166)	(26)	(378)	68
Net loss	$ (22,128)	$ (34,694)	$ (67,733)	$ (90,703)
Basic and diluted net loss per share	$ (0.38)	$ (0.90)	$ (1.36)	$ (2.36)
Weighted average shares used to compute basic and diluted net loss per share	57,650	38,512	49,785	38,493

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