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v3.8.0.1

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenues: |  |  |
Collaboration revenue |  | $ 9,778 | $ 2,765
Grant revenue | $ 295 | 381 | 683
Service and license revenue | 32 | 884 | 602
Total revenues | 327 | 11,043 | 4,050
Operating expenses: |  |  |
Amortization of intangible assets | 1,194 |  |
Research and development | 64,988 | 84,493 | 86,943
Selling, general and administrative | 27,367 | 37,257 | 22,180
Restructuring | 2,783 |  |
Total operating expenses | 96,332 | 121,750 | 109,123
Loss from operations | (96,005) | (110,707) | (105,073)
Other income (expense): |  |  |
Interest income | 1,337 | 755 | 205
Interest expense |  |  | (572)
Other (expense) income, net | (486) | (2,492) | 317
Loss on extinguishment of debt |  |  | (1,671)
Net loss | $ (95,154) | $ (112,444) | $ (106,794)
Basic and diluted net loss per share | $ (1.81) | $ (2.92) | $ (3.25)
Weighted average shares used to compute basic and diluted net loss per share | 52,613 | 38,506 | 32,881

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