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Commitments and Contingencies - Additional Information (Detail) € in Millions |  |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Oct. 24, 2017 USD ($) | Sep. 07, 2016 USD ($) | Nov. 30, 2009 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2004 USD ($) | Dec. 31, 2017 EUR (€) | Dec. 31, 2016 EUR (€)
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Reversal of deferred rent liability |  |  |  | $ 209,000 |  |  |  |  |
Rent expense, net |  |  |  | 2,400,000 | $ 2,200,000 | $ 2,000,000 |  |  |
Deferred rent |  |  |  | 600,000 | 300,000 |  |  |  |
Accrued gain (loss) on lease |  |  |  |  | (300,000) |  |  |  |
Cash, cash equivalents and marketable securities |  |  |  | $ 191,900,000 |  |  |  |  |
Litigation settlement agreement date |  |  |  | September 7, 2016 |  |  |  |  |
Litigation amount payable | $ 900,000 |  |  |  |  |  |  |  |
Estimated loss accrual on litigation |  |  |  |  | 4,975,000 |  |  |  |
Accrued Liabilities |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Anticipated recovery on litigation |  |  |  |  | 900,000 |  |  |  |
Prepaid Expenses and Other Current Assets |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Anticipated recovery on litigation |  |  |  |  | 900,000 |  |  |  |
Dynavax Technologies Securities Litigation |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Litigation amount payable |  | $ 4,100,000 |  |  |  |  |  |  |
Dynavax Technologies Securities Litigation | Accrued Liabilities |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Estimated loss accrual on litigation |  |  |  |  | 4,100,000 |  |  |  |
Dynavax Technologies Securities Litigation | Prepaid Expenses and Other Current Assets |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Anticipated recovery on litigation |  |  |  |  | 4,100,000 |  |  |  |
Symphony Dynamo, Inc. |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
License arrangement contingent consideration percentage |  |  | 50.00% |  |  |  |  |  |
License arrangement upfront payment |  |  | $ 50,000,000 |  |  |  |  |  |
Milestone payments |  |  |  | $ 0 |  |  |  |  |
Deutsche Bank Securities |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Letter of credit pledged as security | € |  |  |  |  |  |  |  | € 0.2 |
Collateralized certificate of deposit | € |  |  |  |  |  |  |  | € 0.2 | € 0.2
Berkeley, California (the "Berkeley Lease") |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Operating leases expiration date |  |  |  | 2025-12 |  |  |  |  |
Letter of credit pledged as security |  |  |  |  |  |  | $ 400,000 |  |
Collateralized certificate of deposit |  |  |  | $ 400,000 | $ 400,000 |  |  |  |
Terms of the lease |  |  |  | If the total amount of our cash, cash equivalents and marketable securities falls below $20 million for a period of more than 30 consecutive days during the lease term, the amount of the required security deposit will increase to $1.1 million, until such time as our projected cash and cash equivalents will exceed $20 million for the remainder of the lease term, or until our actual cash and cash equivalents remains above $20 million for a period of 12 consecutive months. |  |  |  |  |
Berkeley, California (the "Berkeley Lease") | Contingency, B |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Contingency period for cash, cash equivalents and marketable securities |  |  |  |  |  |  | 12 months |  |
Berkeley, California (the "Berkeley Lease") | Contingency, B | Minimum |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Cash, cash equivalents and marketable securities |  |  |  |  |  |  | $ 20,000,000 |  |
Berkeley, California (the "Berkeley Lease") | Contingency, A |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Increase in amount of the security deposit |  |  |  |  |  |  | $ 1,100,000 |  |
Berkeley, California (the "Berkeley Lease") | Contingency, A | Minimum |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Contingency period for cash, cash equivalents and marketable securities |  |  |  |  |  |  | 30 days |  |
Berkeley, California (the "Berkeley Lease") | Contingency, A | Maximum |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Cash, cash equivalents and marketable securities |  |  |  |  |  |  | $ 20,000,000 |  |
Dusseldorf, Germany (the "Dusseldorf Lease") |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Operating leases expiration date |  |  |  | 2023-03 |  |  |  |  |

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