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Component of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carry forwards | $ 146,300 | $ 249,510
Research tax credit carry forwards | 29,658 | 29,463
Accruals and reserves | 6,551 | 8,684
Capitalized research costs | 1,422 | 4,457
Other | 731 | 1,303
Total deferred tax assets | 184,662 | 293,417
Less valuation allowance | (184,388) | (293,145)
Net deferred tax assets | 274 | 272
Deferred tax liabilities: |  |
Fixed assets | (274) | (272)
Total deferred tax liabilities | $ (274) | $ (272)

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