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Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |  |
Stock-based compensation expense | $ 14,917 | $ 14,126 | $ 9,316
Employees And Directors |  |  |
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |  |
Stock-based compensation expense | 14,917 | 14,126 | 9,316
Research and Development |  |  |
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |  |
Stock-based compensation expense | 7,827 | 6,742 | 4,123
Selling, General and Administrative |  |  |
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |  |
Stock-based compensation expense | $ 7,090 | $ 7,384 | $ 5,193

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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