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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:      
Collaboration revenue   $ 9,778 $ 2,765
Grant revenue $ 295 381 683
Service and license revenue 32 884 602
Total revenues 327 11,043 4,050
Operating expenses:      
Amortization of intangible assets 1,194    
Research and development 64,988 84,493 86,943
Selling, general and administrative 27,367 37,257 22,180
Restructuring 2,783    
Total operating expenses 96,332 121,750 109,123
Loss from operations (96,005) (110,707) (105,073)
Other income (expense):      
Interest income 1,337 755 205
Interest expense     (572)
Other (expense) income, net (486) (2,492) 317
Loss on extinguishment of debt     (1,671)
Net loss $ (95,154) $ (112,444) $ (106,794)
Basic and diluted net loss per share $ (1.81) $ (2.92) $ (3.25)
Weighted average shares used to compute basic and diluted net loss per share 52,613 38,506 32,881