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Commitments and Contingencies - Additional Information (Detail)
€ in Millions
1 Months Ended 12 Months Ended
Oct. 24, 2017
USD ($)
Sep. 07, 2016
USD ($)
Nov. 30, 2009
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2004
USD ($)
Dec. 31, 2017
EUR (€)
Dec. 31, 2016
EUR (€)
Loss Contingencies [Line Items]                  
Reversal of deferred rent liability       $ 209,000          
Rent expense, net       2,400,000 $ 2,200,000 $ 2,000,000      
Deferred rent       600,000 300,000        
Accrued gain (loss) on lease         (300,000)        
Cash, cash equivalents and marketable securities       $ 191,900,000          
Litigation settlement agreement date       September 7, 2016          
Litigation amount payable $ 900,000                
Estimated loss accrual on litigation         4,975,000        
Accrued Liabilities                  
Loss Contingencies [Line Items]                  
Anticipated recovery on litigation         900,000        
Prepaid Expenses and Other Current Assets                  
Loss Contingencies [Line Items]                  
Anticipated recovery on litigation         900,000        
Dynavax Technologies Securities Litigation                  
Loss Contingencies [Line Items]                  
Litigation amount payable   $ 4,100,000              
Dynavax Technologies Securities Litigation | Accrued Liabilities                  
Loss Contingencies [Line Items]                  
Estimated loss accrual on litigation         4,100,000        
Dynavax Technologies Securities Litigation | Prepaid Expenses and Other Current Assets                  
Loss Contingencies [Line Items]                  
Anticipated recovery on litigation         4,100,000        
Symphony Dynamo, Inc.                  
Loss Contingencies [Line Items]                  
License arrangement contingent consideration percentage     50.00%            
License arrangement upfront payment     $ 50,000,000            
Milestone payments       $ 0          
Deutsche Bank Securities                  
Loss Contingencies [Line Items]                  
Letter of credit pledged as security | €               € 0.2  
Collateralized certificate of deposit | €               € 0.2 € 0.2
Berkeley, California (the "Berkeley Lease")                  
Loss Contingencies [Line Items]                  
Operating leases expiration date       2025-12          
Letter of credit pledged as security             $ 400,000    
Collateralized certificate of deposit       $ 400,000 $ 400,000        
Terms of the lease       If the total amount of our cash, cash equivalents and marketable securities falls below $20 million for a period of more than 30 consecutive days during the lease term, the amount of the required security deposit will increase to $1.1 million, until such time as our projected cash and cash equivalents will exceed $20 million for the remainder of the lease term, or until our actual cash and cash equivalents remains above $20 million for a period of 12 consecutive months.          
Berkeley, California (the "Berkeley Lease") | Contingency, B                  
Loss Contingencies [Line Items]                  
Contingency period for cash, cash equivalents and marketable securities             12 months    
Berkeley, California (the "Berkeley Lease") | Contingency, B | Minimum                  
Loss Contingencies [Line Items]                  
Cash, cash equivalents and marketable securities             $ 20,000,000    
Berkeley, California (the "Berkeley Lease") | Contingency, A                  
Loss Contingencies [Line Items]                  
Increase in amount of the security deposit             $ 1,100,000    
Berkeley, California (the "Berkeley Lease") | Contingency, A | Minimum                  
Loss Contingencies [Line Items]                  
Contingency period for cash, cash equivalents and marketable securities             30 days    
Berkeley, California (the "Berkeley Lease") | Contingency, A | Maximum                  
Loss Contingencies [Line Items]                  
Cash, cash equivalents and marketable securities             $ 20,000,000    
Dusseldorf, Germany (the "Dusseldorf Lease")                  
Loss Contingencies [Line Items]                  
Operating leases expiration date       2023-03