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Summary of Revenue Recognized under Various Agreements (Detail) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Product Information [Line Items]                      
Total revenues $ 21 $ 53 $ 105 $ 148 $ 7,292 $ 162 $ 2,647 $ 942 $ 327 $ 11,043 $ 4,050
Astra Zeneca                      
Product Information [Line Items]                      
Initial and milestone payment                   7,722 238
Subsequent payment                   1,953 892
Performance of research activities         $ 7,200         103 1,635
Total revenues                   $ 9,778 $ 2,765