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Difference between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Income tax benefit at federal statutory rate	$ (32,352,000)	$ (38,183,000)	$ (36,301,000)
State tax	(4,482,000)	(334,000)	(394,000)
Business credits	(1,960,000)	(1,950,000)	(2,622,000)
Deferred compensation charges	3,823,000	3,016,000	1,481,000
Change in valuation allowance	(109,165,000)	36,751,000	36,766,000
Rate change	86,943,000
Net operating loss and tax credit limitation	56,962,000
Other	231,000	700,000	1,070,000
Total income tax expense	$ 0	$ 0	$ 0

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to tax credits. Including, but not limited to, research credit, foreign tax credit, investment tax credit, and other tax credits.

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