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Selected Quarterly Financial Data (Detail) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]                      
Revenues $ 21 $ 53 $ 105 $ 148 $ 7,292 $ 162 $ 2,647 $ 942 $ 327 $ 11,043 $ 4,050
Net loss $ (27,421) $ (22,128) $ (20,318) $ (25,287) $ (21,741) $ (34,694) $ (28,986) $ (27,023) $ (95,154) $ (112,444) $ (106,794)
Basic and diluted net loss per share $ (0.45) $ (0.38) $ (0.41) $ (0.60) $ (0.56) $ (0.90) $ (0.75) $ (0.70) $ (1.81) $ (2.92) $ (3.25)
Weighted average shares used to compute basic and diluted net loss per share 61,007 57,650 49,700 41,830 38,544 38,512 38,496 38,472 52,613 38,506 32,881