Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
Mar. 31, 2018	Mar. 31, 2017
Revenues:
Product revenue, net	$ 165
Grant revenue		$ 148
Total revenues	165	148
Operating expenses:
Cost of sales - product	205
Cost of sales - amortization of intangible assets	2,417
Research and development	18,966	16,345
Selling, general and administrative	16,891	6,472
Restructuring		2,783
Total operating expenses	38,479	25,600
Loss from operations	(38,314)	(25,452)
Other income (expense):
Interest income	740	145
Interest expense	(1,161)
Other (expense) income, net	(223)	20
Net loss	$ (38,958)	$ (25,287)
Basic and diluted net loss per share	$ (0.63)	$ (0.60)
Weighted average shares used to compute basic and diluted net loss per share	61,744	41,830

Total costs related to goods produced and sold during the reporting period.

Name:	us-gaap_CostOfGoodsSold
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

The amount of expense recognized in the current period that reflects the allocation of the costs of intangible assets over the expected benefit period of such assets. This element applies only to intangible assets used in the production of goods.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.2(a))
-URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688