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Collaborative Research, Development and License Agreements - Additional Information (Detail)
1 Months Ended 3 Months Ended
Mar. 31, 2018
USD ($)
Feb. 28, 2018
USD ($)
Installment
Jan. 31, 2018
USD ($)
Mar. 31, 2020
USD ($)
Mar. 31, 2019
USD ($)
Mar. 31, 2018
USD ($)
Merck, Sharp & Dohme Corp. | Sublicense Agreement            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Aggregate amount payable to acquire intangible assets   $ 21,000,000        
Number of installments | Installment   3        
Payment upon obligation   $ 7,000,000        
Intangible assets   $ 19,800,000        
Merck, Sharp & Dohme Corp. | Sublicense Agreement | Scenario, Forecast            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Payment upon obligation       $ 7,000,000 $ 7,000,000  
Coley Pharmaceutical Group, Inc.            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Agreement termination date           2018-02
Amortization of intangible assets $ 2,500,000          
Coley Pharmaceutical Group, Inc. | Intangible Assets            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Payment for regulatory milestones recorded as intangible asset     $ 2,500,000      
Maximum            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Additional milestone payments eligible to be received based on achievement of certain development and regulatory objectives $ 100,000,000         $ 100,000,000