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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Operating activities    
Net loss $ (38,958) $ (25,287)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 823 789
Gain on disposal of property and equipment   (21)
Accretion of discounts on marketable securities (176) (10)
Stock compensation expense 4,799 3,821
Cost of sales - amortization of intangible assets 2,417  
Non-cash interest expense 348  
Changes in operating assets and liabilities:    
Accounts and other receivables 91 (123)
Inventories (238)  
Prepaid expenses and other current assets 394 (39)
Other assets 3 (907)
Accounts payable 349 (2,110)
Accrued liabilities and other long term liabilities 276 (1,363)
Net cash used in operating activities (29,872) (25,250)
Investing activities    
Acquisition of technology licenses (9,500)  
Purchases of marketable securities (141,103) (44,652)
Proceeds from maturities of marketable securities 91,815 37,875
Purchases of property and equipment, net (897) (234)
Net cash used in investing activities (59,685) (7,011)
Financing activities    
Proceeds from long-term debt, net 99,000  
Proceeds from issuance of common stock, net   29,535
Tax withholding from exercise of stock options and restricted stock awards, net (426) (303)
Proceeds from Employee Stock Purchase Plan 255 155
Net cash provided by financing activities 98,829 29,387
Effect of exchange rate changes on cash, cash equivalents and restricted cash 217 60
Net increase (decrease) in cash, cash equivalents and restricted cash 9,489 (2,814)
Cash, cash equivalents and restricted cash at beginning of period 27,213 24,891
Cash, cash equivalents and restricted cash at end of period 36,702 22,077
Supplemental disclosure of cash flow information    
Cash paid during the period for interest 813  
Release of accrual for litigation settlement and insurance recovery (Note 6)   $ 4,050
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 37  
Non-cash acquisition of technology license $ 12,773