Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended	6 Months Ended
Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Total revenues	$ 1,254	$ 105	$ 1,419	$ 253
Operating expenses:
Cost of sales - amortization of intangible assets			4,715
Research and development	16,273	14,814	35,239	31,159
Selling, general and administrative	15,653	5,612	32,544	12,084
Restructuring				2,783
Total operating expenses	39,401	20,426	77,880	46,026
Loss from operations	(38,147)	(20,321)	(76,461)	(45,773)
Other income (expense):
Interest income	1,153	235	1,893	380
Interest expense	(2,691)		(3,852)
Other income (expense), net	241	(232)	18	(212)
Net loss	$ (39,444)	$ (20,318)	$ (78,402)	$ (45,605)
Basic and diluted net loss per share	$ (0.63)	$ (0.41)	$ (1.26)	$ (1.00)
Weighted average shares used to compute basic and diluted net loss per share	62,346	49,700	62,047	45,787
Product
Revenues:
Total revenues	$ 1,254		$ 1,419
Operating expenses:
Cost of sales - product	5,177		5,382
Cost of sales - amortization of intangible assets	$ 2,298		$ 4,715
Grant Revenue
Revenues:
Total revenues		$ 105		$ 253

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

Name:	us-gaap_CostOfGoodsAndServicesSold
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Amount of expense for allocation of cost of intangible asset over its useful life directly used in production of good and rendering of service.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(b)(2))
-URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227