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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Operating activities    
Net loss $ (78,402) $ (45,605)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,658 1,674
Gain on disposal of property and equipment   (24)
Accretion of discounts on marketable securities (681) (35)
Reversal of deferred rent upon lease amendment   (209)
Stock compensation expense 11,089 7,184
Cost of sales - amortization of intangible assets 4,715  
Non-cash interest expense 1,139  
Changes in operating assets and liabilities:    
Accounts and other receivables (450) 532
Inventories (4,800)  
Prepaid expenses and other current assets (186) (1,642)
Other assets (834) 81
Accounts payable 1,623 (2,934)
Accrued liabilities and other long term liabilities 1,330 (1,664)
Net cash used in operating activities (63,799) (42,642)
Investing activities    
Acquisition of technology licenses (9,500)  
Purchases of marketable securities (186,821) (93,045)
Proceeds from maturities of marketable securities 165,450 60,875
Purchases of property and equipment, net (1,639) (242)
Net cash used in investing activities (32,510) (32,412)
Financing activities    
Proceeds from long-term debt, net 99,000  
Proceeds from issuance of common stock, net   88,200
Tax withholding from exercise of stock options and restricted stock awards, net (549) (303)
Proceeds from Employee Stock Purchase Plan 255 155
Net cash provided by financing activities 98,706 88,052
Effect of exchange rate changes on cash, cash equivalents and restricted cash (260) 405
Net increase in cash, cash equivalents and restricted cash 2,137 13,403
Cash, cash equivalents and restricted cash at beginning of period 27,213 24,891
Cash, cash equivalents and restricted cash at end of period 29,350 38,294
Supplemental disclosure of cash flow information    
Cash paid during the period for interest 2,713  
Release of accrual for litigation settlement and insurance recovery (Note 6)   $ 4,050
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 42  
Non-cash acquisition of technology license $ 12,773