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Organization and Summary of Significant Accounting Policies - Additional Information (Detail)
1 Months Ended 9 Months Ended
Nov. 30, 2017
Sep. 30, 2018
USD ($)
Segment
Sep. 30, 2017
USD ($)
Feb. 20, 2018
USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Number of operating segment | Segment   1    
Cash, cash equivalents and marketable securities   $ 180,200,000    
Cash used in operating activities   97,671,000 $ 59,769,000  
Impairment of Intangible assets   $ 0    
Federal corporate income tax rate   21.00%    
Maximum        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Expected period of payment to be received   1 year    
Provisional amounts expected measurement period   1 year    
Patent License Agreements        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Paid fees under patent license agreements   $ 11,000,000    
CRG Servicing LLC        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Additional borrowing capacity       $ 75,000,000
Loan agreement market capitalization requirement       $ 300,000,000
HEPLISAV-B®        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Minimum age approved for vaccine prevention of infection caused 18 years