Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Total revenues	$ 1,461	$ 53	$ 2,880	$ 306
Operating expenses:
Cost of sales - amortization of intangible assets	3,800		8,538
Research and development	16,820	16,417	52,059	47,576
Selling, general and administrative	15,788	6,027	48,332	18,111
Restructuring				2,783
Total operating expenses	40,358	22,444	118,238	68,470
Loss from operations	(38,897)	(22,391)	(115,358)	(68,164)
Other income (expense):
Interest income	1,047	429	2,940	809
Interest expense	(2,735)		(6,587)
Other income (expense), net	57	(166)	75	(378)
Net loss	$ (40,528)	$ (22,128)	$ (118,930)	$ (67,733)
Basic and diluted net loss per share	$ (0.65)	$ (0.38)	$ (1.91)	$ (1.36)
Weighted average shares used to compute basic and diluted net loss per share	62,650	57,650	62,250	49,785
Product
Revenues:
Total revenues	$ 1,461		$ 2,880
Operating expenses:
Cost of sales - product	3,927		9,309
Cost of sales - amortization of intangible assets	$ 3,823		$ 8,538
Grant Revenue
Revenues:
Total revenues		$ 53		$ 306

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

Name:	us-gaap_CostOfGoodsAndServicesSold
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Amount of expense for allocation of cost of intangible asset over its useful life directly used in production of good and rendering of service.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(b)(2))
-URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227