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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Income Tax Disclosure [Line Items] |  |  |
Income tax expense | $ 0 | $ 0 | $ 0
Increase (decrease) in valuation allowance | $ 40,400,000 | (108,800,000) |
Federal corporate income tax rate | 21.00% |  |
Unrecognized tax benefits | $ 1,229,000 | $ 1,229,000 |
Unrecognized tax benefits would affect the effective tax rate | 0 |  |
Interest related to unrecognized tax benefits | 0 |  |
Penalties related to unrecognized tax benefits | 0 |  |
Federal |  |  |
Income Tax Disclosure [Line Items] |  |  |
Net operating loss carryforwards | $ 771,800,000 |  |
Federal | Minimum |  |  |
Income Tax Disclosure [Line Items] |  |  |
Net operating loss carryforwards, expiration year | 2019 |  |
Federal | Research And Development Tax Credits |  |  |
Income Tax Disclosure [Line Items] |  |  |
Tax credit carryforward amount | $ 19,900,000 |  |
Federal | Research And Development Tax Credits | Minimum |  |  |
Income Tax Disclosure [Line Items] |  |  |
Tax credit carryforward amount, expiration year | 2019 |  |
Federal | Research And Development Tax Credits | Maximum |  |  |
Income Tax Disclosure [Line Items] |  |  |
Tax credit carryforward amount, expiration year | 2038 |  |
California and Other States |  |  |
Income Tax Disclosure [Line Items] |  |  |
Net operating loss carryforwards | $ 229,000,000 |  |
California and Other States | Minimum |  |  |
Income Tax Disclosure [Line Items] |  |  |
Net operating loss carryforwards, expiration year | 2019 |  |
California and Other States | Maximum |  |  |
Income Tax Disclosure [Line Items] |  |  |
Net operating loss carryforwards, expiration year | 2038 |  |
California State | Research And Development Tax Credits |  |  |
Income Tax Disclosure [Line Items] |  |  |
Tax credit carryforward amount | $ 19,100,000 |  |
Foreign |  |  |
Income Tax Disclosure [Line Items] |  |  |
Net operating loss carryforwards | $ 11,900,000 |  |

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- Definition Percentage of domestic federal statutory tax rate applicable to pretax income (loss). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 6.I) -URI http://asc.fasb.org/extlink&oid=34349781&loc=d3e330036-122817 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32698-109319 + Details
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