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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2018
Income Tax Disclosure [Abstract] |
Component of Consolidated (Loss) Income Before Provision for Income Taxes | Consolidated (loss) income before provision for income taxes consisted of the following (in thousands):
|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
U.S. |  | $ | (160,032 | ) |  | $ | (95,898 | ) |  | $ | (114,484 | )
Non U.S. |  |  | 1,133 |  |  |  | 744 |  |  |  | 2,040 |
Total |  | $ | (158,899 | ) |  | $ | (95,154 | ) |  | $ | (112,444 | )
Difference Between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate | No income tax expense was recorded for the years ended December 31, 2018, 2017 and 2016 due to our full valuation allowance position. The difference between the consolidated income tax benefit and the amount computed by applying the federal statutory income tax rate to the consolidated loss before income taxes was as follows (in thousands):
|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Income tax benefit at federal statutory rate |  | $ | (33,366 | ) |  | $ | (32,352 | ) |  | $ | (38,183 | )
State tax |  |  | (5,591 | ) |  |  | (4,482 | ) |  |  | (334 | )
Business credits |  |  | (3,065 | ) |  |  | (1,960 | ) |  |  | (1,950 | )
Deferred compensation charges |  |  | (1,165 | ) |  |  | 3,823 |  |  |  | 3,016 |
Change in valuation allowance |  |  | 43,134 |  |  |  | (109,165 | ) |  |  | 36,751 |
Rate change |  |  | - |  |  |  | 86,943 |  |  |  | - |
Net operating loss and tax credit limitation |  |  | - |  |  |  | 56,962 |  |  |  | - |
Other |  |  | 53 |  |  |  | 231 |  |  |  | 700 |
Total income tax expense |  | $ | - |  |  | $ | - |  |  | $ | - |
Component of Deferred Tax Assets and Liabilities | Deferred tax assets and liabilities consisted of the following (in thousands):
|  | December 31, |
|  | 2018 |  |  | 2017 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carry forwards |  | $ | 178,730 |  |  | $ | 146,300 |
Research tax credit carry forwards |  |  | 34,064 |  |  |  | 29,658 |
Accruals and reserves |  |  | 10,137 |  |  |  | 6,551 |
Capitalized research costs |  |  | 943 |  |  |  | 1,422 |
Other |  |  | 1,147 |  |  |  | 731 |
Total deferred tax assets |  |  | 225,021 |  |  |  | 184,662 |
Less valuation allowance |  |  | (224,746 | ) |  |  | (184,388 | )
Net deferred tax assets |  |  | 275 |  |  |  | 274 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Fixed assets |  |  | (275 | ) |  |  | (274 | )
Total deferred tax liabilities |  |  | (275 | ) |  |  | (274 | )
Net deferred tax assets |  | $ | - |  |  | $ | - |
Schedule of Unrecognized Tax Benefits | The following table summarizes the activity related to our unrecognized tax benefits:
Balance at December 31, 2017 |  | $ | (1,229 | )
Tax positions related to the current year |  |  |  |
Additions |  |  | - |
Reductions |  |  | - |
Tax positions related to the prior year |  |  |  |
Additions |  |  | - |
Reductions |  |  | - |
Balance at December 31, 2018 |  | $ | (1,229 | )

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