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Component of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carry forwards | $ 178,730 | $ 146,300
Research tax credit carry forwards | 34,064 | 29,658
Accruals and reserves | 10,137 | 6,551
Capitalized research costs | 943 | 1,422
Other | 1,147 | 731
Total deferred tax assets | 225,021 | 184,662
Less valuation allowance | (224,746) | (184,388)
Net deferred tax assets | 275 | 274
Deferred tax liabilities: |  |
Fixed assets | (275) | (274)
Total deferred tax liabilities | $ (275) | $ (274)

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