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Commitments and Contingencies - Additional Information (Detail) € in Millions |  |  |  | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Sep. 17, 2018 USD ($) ft² | Oct. 24, 2017 USD ($) | Sep. 07, 2016 USD ($) | Feb. 29, 2020 USD ($) | Feb. 28, 2019 USD ($) | Feb. 28, 2018 USD ($) | Nov. 30, 2009 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2004 USD ($) | Dec. 31, 2018 EUR (€) | Dec. 31, 2017 EUR (€) | Dec. 31, 2004 EUR (€)
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Rent expense |  |  |  |  |  |  |  | $ 4,000,000 | $ 2,400,000 | $ 2,200,000 |  |  |  |
Deferred rent |  |  |  |  |  |  |  | 2,300,000 | 600,000 |  |  |  |  |
Maximum borrowing capacity |  |  |  |  |  | $ 175,000,000 |  |  |  |  |  |  |  |
Principal amount including interest paid in kind |  |  |  |  |  | $ 101,800,000 |  |  |  |  |  |  |  |
Debt maturity date |  |  |  |  |  | Dec. 31, 2023 |  |  |  |  |  |  |  |
Cash, cash equivalents and marketable securities |  |  |  |  |  |  |  | $ 145,500,000 |  |  |  |  |  |
Litigation settlement agreement date |  |  |  |  |  |  |  | September 7, 2016 |  |  |  |  |  |
Litigation amount payable |  | $ 900,000 |  |  |  |  |  |  |  |  |  |  |  |
Dynavax Technologies Securities Litigation |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Litigation amount payable |  |  | $ 4,100,000 |  |  |  |  |  |  |  |  |  |  |
Symphony Dynamo Holdings LLC |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License arrangement contingent consideration percentage |  |  |  |  |  |  | 50.00% |  |  |  |  |  |  |
License arrangement upfront payment |  |  |  |  |  |  | $ 50,000,000 |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  |  |  | $ 0 | 0 |  |  |  |  |
Deutsche Bank Securities |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Letter of credit pledged as security | € |  |  |  |  |  |  |  |  |  |  |  |  |  | € 0.2
Collateralized certificate of deposit | € |  |  |  |  |  |  |  |  |  |  |  | € 0.2 | € 0.2 |
Sublicense Agreement | Merck |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment upon obligation |  |  |  |  |  | $ 7,000,000 |  |  |  |  |  |  |  |
Scenario, Forecast | Sublicense Agreement | Merck |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment upon obligation |  |  |  | $ 7,000,000 | $ 7,000,000 |  |  |  |  |  |  |  |  |
Emeryville, California (Premises) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Letter of credit pledged as security |  |  |  |  |  |  |  |  |  |  | $ 400,000 |  |  |
Collateralized certificate of deposit |  |  |  |  |  |  |  | $ 400,000 | $ 400,000 |  |  |  |  |
Terms of the lease |  |  |  |  |  |  |  | If the total amount of our cash, cash equivalents and marketable securities falls below $20 million for a period of more than 30 consecutive days during the lease term, the amount of the required security deposit will increase to $1.1 million, until such time as our projected cash and cash equivalents will exceed $20 million for the remainder of the lease term, or until our actual cash and cash equivalents remains above $20 million for a period of 12 consecutive months. |  |  |  |  |  |
Emeryville, California (Premises) | Contingency, B |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingency period for cash, cash equivalents and marketable securities |  |  |  |  |  |  |  |  |  |  | 12 months |  |  |
Emeryville, California (Premises) | Contingency, A |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase in amount of the security deposit |  |  |  |  |  |  |  |  |  |  | $ 1,100,000 |  |  |
Emeryville, California (Premises) | Maximum | Contingency, A |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash, cash equivalents and marketable securities |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  |
Emeryville, California (Premises) | Minimum | Contingency, B |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash, cash equivalents and marketable securities |  |  |  |  |  |  |  |  |  |  | $ 20,000,000 |  |  |
Emeryville, California (Premises) | Minimum | Contingency, A |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingency period for cash, cash equivalents and marketable securities |  |  |  |  |  |  |  |  |  |  | 30 days |  |  |
Office and Laboratory Space | Emeryville, California (Premises) |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease area | ft² | 75,662 |  |  |  |  |  |  |  |  |  |  |  |  |
Base rent per square feet | $ 4.75 |  |  |  |  |  |  |  |  |  |  |  |  |
Operations commencement date | Apr. 01, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |
Initial lease term | 12 years |  |  |  |  |  |  |  |  |  |  |  |  |
Lease option to extend | The Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms |  |  |  |  |  |  |  |  |  |  |  |  |
Renewal term of lease | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |
Office and Laboratory Space | Emeryville, California (Premises) | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Tenant improvement allowance | $ 8,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |

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