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v3.10.0.1

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Revenues: |  |  |
Total revenues | $ 8,198 | $ 327 | $ 11,043
Operating expenses: |  |  |
Cost of sales - amortization of intangible assets | 10,862 | 1,194 |
Research and development | 74,951 | 64,988 | 84,493
Selling, general and administrative | 64,770 | 27,367 | 37,257
Restructuring |  | 2,783 |
Total operating expenses | 161,517 | 96,332 | 121,750
Loss from operations | (153,319) | (96,005) | (110,707)
Other income (expense): |  |  |
Interest income | 3,828 | 1,337 | 755
Interest expense | (9,338) |  |
Other expense, net | (70) | (486) | (2,492)
Net loss | $ (158,899) | $ (95,154) | $ (112,444)
Basic and diluted net loss per share | $ (2.55) | $ (1.81) | $ (2.92)
Weighted average shares used to compute basic and diluted net loss per share | 62,362 | 52,613 | 38,506
Product |  |  |
Revenues: |  |  |
Total revenues | $ 6,812 |  |
Operating expenses: |  |  |
Cost of sales - product | 10,934 |  |
Cost of sales - amortization of intangible assets | 10,862 | $ 1,194 |
Collaboration Revenue |  |  |
Revenues: |  |  |
Total revenues | $ 1,386 |  | $ 9,778
Grant Revenue |  |  |
Revenues: |  |  |
Total revenues |  | 295 | 381
Service and License Revenue |  |  |
Revenues: |  |  |
Total revenues |  | $ 32 | $ 884

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