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v3.10.0.1

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Operating activities |  |  |
Net loss | $ (158,899,000) | $ (95,154,000) | $ (112,444,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 3,621,000 | 3,244,000 | 2,257,000
Write-off of assets in progress |  |  | 862,000
Loss (gain) on disposal of property and equipment | 98,000 | (10,000) | 91,000
Accretion of discounts and amortization of premiums on marketable securities | (1,559,000) | (193,000) | 178,000
Reversal of deferred rent upon lease amendment |  | (209,000) |
Cash-settled portion of stock compensation expense | 0 | 0 | 602,000
Stock compensation expense | 23,478,000 | 14,917,000 | 14,126,000
Cost of sales - amortization of intangible assets | 10,862,000 | 1,194,000 |
Non-cash interest expense | 2,755,000 |  |
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables | (2,850,000) | 488,000 | 52,000
Inventories, net | (18,710,000) | (312,000) |
Prepaid expenses and other current assets | (2,405,000) | (1,830,000) | 560,000
Other assets | (3,706,000) | (936,000) | (103,000)
Accounts payable | 3,417,000 | (1,915,000) | 1,181,000
Accrued liabilities and other long term liabilities | 12,597,000 | 3,198,000 | (11,759,000)
Deferred revenues |  |  | (2,654,000)
Net cash used in operating activities | (131,301,000) | (77,518,000) | (107,051,000)
Investing activities |  |  |
Acquisition of technology licenses | (11,000,000) |  |
Purchases of marketable securities | (213,804,000) | (227,672,000) | (126,754,000)
Proceeds from maturities of marketable securities | 284,457,000 | 119,638,000 | 220,760,000
Purchases of property and equipment, net | (4,187,000) | (669,000) | (7,757,000)
Net cash provided by (used in) investing activities | 55,466,000 | (108,703,000) | 86,249,000
Financing activities |  |  |
Proceeds from long-term debt, net | 99,000,000 |  |
Proceeds from issuances of common stock, net |  | 185,936,000 |
(Tax withholding) proceeds from exercise of stock options and restricted stock awards, net | (523,000) | 1,613,000 | (84,000)
Proceeds from Employee Stock Purchase Plan | 594,000 | 293,000 | 615,000
Net cash provided by financing activities | 99,071,000 | 187,842,000 | 531,000
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (482,000) | 701,000 | (259,000)
Net increase (decrease) in cash, cash equivalents and restricted cash | 22,754,000 | 2,322,000 | (20,530,000)
Cash, cash equivalents and restricted cash at beginning of year | 27,213,000 | 24,891,000 | 45,421,000
Cash, cash equivalents and restricted cash at end of year | 49,967,000 | 27,213,000 | 24,891,000
Supplemental disclosure of cash flow information |  |  |
Cash paid during the year for interest | 6,583,000 |  |
Accrual for litigation settlement and insurance recovery (Note 9) |  |  | 4,975,000
Release of accrual for litigation settlement and insurance recovery (Note 9) |  | 4,975,000 |
Non-cash investing and financing activities: |  |  |
Disposal of fully depreciated property and equipment | 199,000 | $ 86,000 | 2,354,000
Non-cash acquisition of technology license | $ 12,773,000 |  |
Astra Zeneca |  |  |
Supplemental disclosure of cash flow information |  |  |
Return of unused development funding to AstraZeneca AB |  |  | 7,200,000
Milestone payment from AstraZeneca AB |  |  | $ 7,200,000

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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3151-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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