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Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands | Total | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive (Loss) Income | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Beginning Balances at Dec. 31, 2015 | $ 187,079 | $ 38 | $ 889,698 | $ (2,930) | $ (699,727)
Beginning Balances (in shares) at Dec. 31, 2015 |  | 38,446 |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net | (83) | $ 1 | (84) |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares) |  | 107 |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 615 |  | 615 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 46 |  |  |
Stock compensation expense | 14,728 |  | 14,728 |  |
Total other comprehensive loss | (694) |  |  | (694) |
Net loss | (112,444) |  |  |  | (112,444)
Ending Balances at Dec. 31, 2016 | 89,201 | $ 39 | 904,957 | (3,624) | (812,171)
Ending Balances (in shares) at Dec. 31, 2016 |  | 38,599 |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net | 1,613 |  | 1,613 |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares) |  | 262 |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 293 |  | 293 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 84 |  |  |
Issuance of common stock, net of issuance costs | 185,936 | $ 23 | 185,913 |  |
Issuance of common stock, net of issuance costs (in shares) |  | 22,588 |  |  |
Stock compensation expense | 14,917 |  | 14,917 |  |
Total other comprehensive loss | 2,743 |  |  | 2,743 |
Net loss | (95,154) |  |  |  | (95,154)
Ending Balances at Dec. 31, 2017 | 199,549 | $ 62 | 1,107,693 | (881) | (907,325)
Ending Balances (in shares) at Dec. 31, 2017 |  | 61,533 |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net | (523) | $ 1 | (524) |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares) |  | 1,204 |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 594 |  | 594 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 125 |  |  |
Stock compensation expense | 23,478 |  | 23,478 |  |
Total other comprehensive loss | (1,134) |  |  | (1,134) |
Net loss | (158,899) |  |  |  | (158,899)
Ending Balances at Dec. 31, 2018 | $ 63,065 | $ 63 | $ 1,131,241 | $ (2,015) | $ (1,066,224)
Ending Balances (in shares) at Dec. 31, 2018 |  | 62,862 |  |  |

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