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Equity Plans and Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2018

Share Based Compensation [Abstract]

Option Activity under Stock-Based Compensation Plans

Activity under our stock plans is set forth below:

		Shares Underlying Outstanding Options (in thousands)				Weighted-Average Exercise Price Per Share				Weighted-Average Remaining Contractual Term (years)				Aggregate Intrinsic Value (in thousands)
Balance at December 31, 2017			3,555			$	19.56
Options granted			2,503				16.30
Options exercised			(42	)			11.80
Options cancelled:
Options forfeited (unvested)			(178	)			14.29
Options expired (vested)			(88	)			29.58
Balance at December 31, 2018			5,750			$	18.20				5.47			$	651
Vested and expected to vest at December 31, 2018			5,534			$	18.28				5.44			$	644
Exercisable at December 31, 2018			2,975			$	19.90				4.87			$	466

Summary of Non-vested Restricted Stock Units Activity

Our non-vested stock awards are comprised of restricted stock units granted with performance and time-based vesting criteria. A summary of the status of non-vested restricted stock units as of December 31, 2018, and activities during 2018 are summarized as follows:  

	Number of Shares (In thousands)				Weighted-Average Grant-Date Fair Value
Non-vested as of December 31, 2017		2,443			$	6.01
Granted		458				15.98
Vested		(1,219	)			5.86
Forfeited		(88	)			9.07
Non-vested as of December 31, 2018		1,594			$	8.82

Fair Value-Based Measurements and Weighted-Average Assumptions

The fair value of each option is estimated on the date of grant using the Black-Scholes option valuation model and the following weighted-average assumptions:

		Stock Options												Employee Stock Purchase Plan
		Year Ended December 31,												Year Ended December 31,
		2018				2017				2016				2018				2017				2016
Weighted-average fair value		$	10.75			$	8.27			$	9.54			$	8.30			$	3.05			$	7.86
Risk-free interest rate			2.5	%			1.9	%			1.4	%			2.4	%			1.0	%			0.6	%
Expected life (in years)			4.2				4.5				4.9				1.3				1.2				1.2
Expected Volatility			0.8				0.9				0.7				1.1				1.0				0.6

Stock-Based Compensation Expense

We recognized the following amounts of stock-based compensation expense (in thousands):

		Year Ended December 31,
		2018				2017				2016
Employees and directors stock-based compensation expense		$	23,478			$	14,917			$	14,126
		Year Ended December 31,
		2018				2017				2016
Research and development		$	9,604			$	7,827			$	6,742
Selling, general and administrative			11,761				7,090				7,384
Cost of sales - product			1,354				-				-
Inventory			759				-				-
Total		$	23,478			$	14,917			$	14,126

X

- Definition

Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
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- Definition

Tabular disclosure of number, weighted-average exercise price or conversion ratio, aggregate intrinsic value, and weighted-average remaining contractual term for outstanding options that are fully vested and expected to vest. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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