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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Component of Consolidated (Loss) Income Before Provision for Income Taxes

Consolidated (loss) income before provision for income taxes consisted of the following (in thousands):

		Year Ended December 31,
		2018				2017				2016
U.S.		$	(160,032	)		$	(95,898	)		$	(114,484	)
Non U.S.			1,133				744				2,040
Total		$	(158,899	)		$	(95,154	)		$	(112,444	)

Difference Between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate

No income tax expense was recorded for the years ended December 31, 2018, 2017 and 2016 due to our full valuation allowance position. The difference between the consolidated income tax benefit and the amount computed by applying the federal statutory income tax rate to the consolidated loss before income taxes was as follows (in thousands):

		Year Ended December 31,
		2018				2017				2016
Income tax benefit at federal statutory rate		$	(33,366	)		$	(32,352	)		$	(38,183	)
State tax			(5,591	)			(4,482	)			(334	)
Business credits			(3,065	)			(1,960	)			(1,950	)
Deferred compensation charges			(1,165	)			3,823				3,016
Change in valuation allowance			43,134				(109,165	)			36,751
Rate change			-				86,943				-
Net operating loss and tax credit limitation			-				56,962				-
Other			53				231				700
Total income tax expense		$	-			$	-			$	-

Component of Deferred Tax Assets and Liabilities

Deferred tax assets and liabilities consisted of the following (in thousands): 

		December 31,
		2018				2017
Deferred tax assets:
Net operating loss carry forwards		$	178,730			$	146,300
Research tax credit carry forwards			34,064				29,658
Accruals and reserves			10,137				6,551
Capitalized research costs			943				1,422
Other			1,147				731
Total deferred tax assets			225,021				184,662
Less valuation allowance			(224,746	)			(184,388	)
Net deferred tax assets			275				274
Deferred tax liabilities:
Fixed assets			(275	)			(274	)
Total deferred tax liabilities			(275	)			(274	)
Net deferred tax assets		$	-			$	-

Schedule of Unrecognized Tax Benefits

The following table summarizes the activity related to our unrecognized tax benefits:

Balance at December 31, 2017		$	(1,229	)
Tax positions related to the current year
Additions			-
Reductions			-
Tax positions related to the prior year
Additions			-
Reductions			-
Balance at December 31, 2018		$	(1,229	)

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure of the change in unrecognized tax benefits.

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