Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues:
Total revenues	$ 8,198	$ 327	$ 11,043
Operating expenses:
Cost of sales - amortization of intangible assets	10,862	1,194
Research and development	74,951	64,988	84,493
Selling, general and administrative	64,770	27,367	37,257
Restructuring		2,783
Total operating expenses	161,517	96,332	121,750
Loss from operations	(153,319)	(96,005)	(110,707)
Other income (expense):
Interest income	3,828	1,337	755
Interest expense	(9,338)
Other expense, net	(70)	(486)	(2,492)
Net loss	$ (158,899)	$ (95,154)	$ (112,444)
Basic and diluted net loss per share	$ (2.55)	$ (1.81)	$ (2.92)
Weighted average shares used to compute basic and diluted net loss per share	62,362	52,613	38,506
Product
Revenues:
Total revenues	$ 6,812
Operating expenses:
Cost of sales - product	10,934
Cost of sales - amortization of intangible assets	10,862	$ 1,194
Collaboration Revenue
Revenues:
Total revenues	$ 1,386		$ 9,778
Grant Revenue
Revenues:
Total revenues		295	381
Service and License Revenue
Revenues:
Total revenues		$ 32	$ 884

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

Name:	us-gaap_CostOfGoodsAndServicesSold
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Amount of expense for allocation of cost of intangible asset over its useful life directly used in production of good and rendering of service.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(b)(2))
-URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227