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Commitments and Contingencies - Additional Information (Detail)
€ in Millions
 1 Months Ended 12 Months Ended
Sep. 17, 2018
USD ($)
ft²
Oct. 24, 2017
USD ($)
Sep. 07, 2016
USD ($)
Feb. 29, 2020
USD ($)
Feb. 28, 2019
USD ($)
Feb. 28, 2018
USD ($)
Nov. 30, 2009
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2004
USD ($)
Dec. 31, 2018
EUR (€)
Dec. 31, 2017
EUR (€)
Dec. 31, 2004
EUR (€)
Loss Contingencies [Line Items]                            
Rent expense               $ 4,000,000 $ 2,400,000 $ 2,200,000        
Deferred rent               2,300,000 600,000          
Maximum borrowing capacity           $ 175,000,000                
Principal amount including interest paid in kind           $ 101,800,000                
Debt maturity date           Dec. 31, 2023                
Cash, cash equivalents and marketable securities               $ 145,500,000            
Litigation settlement agreement date               September 7, 2016            
Litigation amount payable   $ 900,000                        
Dynavax Technologies Securities Litigation                            
Loss Contingencies [Line Items]                            
Litigation amount payable     $ 4,100,000                      
Symphony Dynamo Holdings LLC                            
Loss Contingencies [Line Items]                            
License arrangement contingent consideration percentage             50.00%              
License arrangement upfront payment             $ 50,000,000              
Milestone payments               $ 0 0          
Deutsche Bank Securities                            
Loss Contingencies [Line Items]                            
Letter of credit pledged as security | €                           € 0.2
Collateralized certificate of deposit | €                       € 0.2 € 0.2  
Sublicense Agreement | Merck                            
Loss Contingencies [Line Items]                            
Payment upon obligation           $ 7,000,000                
Scenario, Forecast | Sublicense Agreement | Merck                            
Loss Contingencies [Line Items]                            
Payment upon obligation       $ 7,000,000 $ 7,000,000                  
Emeryville, California (Premises)                            
Loss Contingencies [Line Items]                            
Letter of credit pledged as security                     $ 400,000      
Collateralized certificate of deposit               $ 400,000 $ 400,000          
Terms of the lease               If the total amount of our cash, cash equivalents and marketable securities falls below $20 million for a period of more than 30 consecutive days during the lease term, the amount of the required security deposit will increase to $1.1 million, until such time as our projected cash and cash equivalents will exceed $20 million for the remainder of the lease term, or until our actual cash and cash equivalents remains above $20 million for a period of 12 consecutive months.            
Emeryville, California (Premises) | Contingency, B                            
Loss Contingencies [Line Items]                            
Contingency period for cash, cash equivalents and marketable securities                     12 months      
Emeryville, California (Premises) | Contingency, A                            
Loss Contingencies [Line Items]                            
Increase in amount of the security deposit                     $ 1,100,000      
Emeryville, California (Premises) | Maximum | Contingency, A                            
Loss Contingencies [Line Items]                            
Cash, cash equivalents and marketable securities                     20,000,000      
Emeryville, California (Premises) | Minimum | Contingency, B                            
Loss Contingencies [Line Items]                            
Cash, cash equivalents and marketable securities                     $ 20,000,000      
Emeryville, California (Premises) | Minimum | Contingency, A                            
Loss Contingencies [Line Items]                            
Contingency period for cash, cash equivalents and marketable securities                     30 days      
Office and Laboratory Space | Emeryville, California (Premises)                            
Loss Contingencies [Line Items]                            
Lease area | ft² 75,662                          
Base rent per square feet $ 4.75                          
Operations commencement date Apr. 01, 2019                          
Initial lease term 12 years                          
Lease option to extend The Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms                          
Renewal term of lease 5 years                          
Office and Laboratory Space | Emeryville, California (Premises) | Maximum                            
Loss Contingencies [Line Items]                            
Tenant improvement allowance $ 8,300,000