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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2015 $ 187,079 $ 38 $ 889,698 $ (2,930) $ (699,727)
Beginning Balances (in shares) at Dec. 31, 2015   38,446      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (83) $ 1 (84)    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   107      
Issuance of common stock under Employee Stock Purchase Plan 615   615    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   46      
Stock compensation expense 14,728   14,728    
Total other comprehensive loss (694)     (694)  
Net loss (112,444)       (112,444)
Ending Balances at Dec. 31, 2016 89,201 $ 39 904,957 (3,624) (812,171)
Ending Balances (in shares) at Dec. 31, 2016   38,599      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 1,613   1,613    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   262      
Issuance of common stock under Employee Stock Purchase Plan 293   293    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   84      
Issuance of common stock, net of issuance costs 185,936 $ 23 185,913    
Issuance of common stock, net of issuance costs (in shares)   22,588      
Stock compensation expense 14,917   14,917    
Total other comprehensive loss 2,743     2,743  
Net loss (95,154)       (95,154)
Ending Balances at Dec. 31, 2017 199,549 $ 62 1,107,693 (881) (907,325)
Ending Balances (in shares) at Dec. 31, 2017   61,533      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (523) $ 1 (524)    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   1,204      
Issuance of common stock under Employee Stock Purchase Plan 594   594    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   125      
Stock compensation expense 23,478   23,478    
Total other comprehensive loss (1,134)     (1,134)  
Net loss (158,899)       (158,899)
Ending Balances at Dec. 31, 2018 $ 63,065 $ 63 $ 1,131,241 $ (2,015) $ (1,066,224)
Ending Balances (in shares) at Dec. 31, 2018   62,862