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Computation of Basic and Diluted Earnings Per Share (Detail) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Basic and diluted net loss per share (in thousands, except per share amounts):                      
Net loss $ (39,969) $ (40,528) $ (39,444) $ (38,958) $ (27,421) $ (22,128) $ (20,318) $ (25,287) $ (158,899) $ (95,154) $ (112,444)
Denominator for basic and diluted net loss per share:                      
Weighted-average common shares outstanding 62,694 62,650 62,346 61,744 61,007 57,650 49,700 41,830 62,362 52,613 38,506
Basic and diluted net loss per share $ (0.64) $ (0.65) $ (0.63) $ (0.63) $ (0.45) $ (0.38) $ (0.41) $ (0.60) $ (2.55) $ (1.81) $ (2.92)
Stock Options and Stock Awards                      
Outstanding securities not included in diluted net loss per share calculation (in thousands):                      
Outstanding securities not included in diluted net loss per share calculation                 7,344 5,981 4,673