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Difference between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate (Detail) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Income Tax Disclosure [Abstract]      
Income tax benefit at federal statutory rate $ (33,366,000) $ (32,352,000) $ (38,183,000)
State tax (5,591,000) (4,482,000) (334,000)
Business credits (3,065,000) (1,960,000) (1,950,000)
Deferred compensation charges (1,165,000) 3,823,000 3,016,000
Change in valuation allowance 43,134,000 (109,165,000) 36,751,000
Rate change   86,943,000  
Net operating loss and tax credit limitation   56,962,000  
Other 53,000 231,000 700,000
Total income tax expense $ 0 $ 0 $ 0