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Organization and Summary of Significant Accounting Policies - Additional Information (Detail)		1 Months Ended	3 Months Ended
	Feb. 20, 2018 USD ($)	Feb. 28, 2018 USD ($)	Mar. 31, 2019 USD ($) Segment	Mar. 29, 2019 USD ($)	Jan. 01, 2019 USD ($)	Mar. 31, 2018 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Number of operating segment | Segment			1
Cash, cash equivalents and marketable securities			$ 183,200,000
Principal amount including interest paid in kind		$ 177,300,000	$ 177,300,000
Debt maturity date		Dec. 31, 2023	Dec. 31, 2023
Right-of-use asset			$ 33,505,000
Operating lease, liability			36,960,000
Inventory reserve			$ 0			$ 0
ASC 842
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Right-of-use asset					$ 34,800,000
Operating lease, liability					$ 37,100,000
Maximum
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Expected period of payment to be received			1 year
CRG Servicing LLC
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Loan borrowed	$ 100,000,000.0			$ 75,000,000.0
Principal amount including interest paid in kind			$ 177,300,000
Debt maturity date	Dec. 31, 2023
HEPLISAV-B?
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Minimum age approved for vaccine prevention of infection caused			18 years

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