Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
Mar. 31, 2019	Mar. 31, 2018
Revenues:
Total revenues	$ 5,773	$ 165
Operating expenses:
Cost of sales - amortization of intangible assets	2,273	2,417
Research and development	21,206	18,966
Selling, general and administrative	18,348	16,891
Total operating expenses	43,627	38,479
Loss from operations	(37,854)	(38,314)
Other income (expense):
Interest income	735	740
Interest expense	(2,734)	(1,161)
Other income (expense), net	181	(223)
Net loss	$ (39,672)	$ (38,958)
Basic and diluted net loss per share	$ (0.62)	$ (0.63)
Weighted average shares used to compute basic and diluted net loss per share	63,778	61,744
Product
Revenues:
Total revenues	$ 5,627	$ 165
Operating expenses:
Cost of sales - product	1,800	205
Cost of sales - amortization of intangible assets	2,273	$ 2,417
Collaboration Revenue
Revenues:
Total revenues	$ 146

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

Name:	us-gaap_CostOfGoodsAndServicesSold
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Amount of expense for allocation of cost of intangible asset over its useful life directly used in production of good and rendering of service.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(b)(2))
-URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227