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Organization and Summary of Significant Accounting Policies - Additional Information (Detail)
 1 Months Ended 6 Months Ended
May 23, 2019
Position
Feb. 20, 2018
USD ($)
Feb. 28, 2018
USD ($)
Jun. 30, 2019
USD ($)
Segment
Mar. 29, 2019
USD ($)
Jan. 01, 2019
USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Number of positions reduced in global workforce | Position 80          
Percentage of reduction in global workforce 36.00%          
Restructuring completion date       Dec. 31, 2019    
Number of operating segment | Segment       1    
Cash, cash equivalents and marketable securities       $ 140,500,000    
Principal amount including interest paid in kind     $ 178,200,000 $ 178,200,000    
Debt maturity date     Dec. 31, 2023 Dec. 31, 2023    
Right-of-use asset       $ 29,533,000    
Operating lease, liability       36,304,000    
Inventory reserve       $ 0    
ASC 842            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Right-of-use asset           $ 34,800,000
Operating lease, liability           $ 37,100,000
Maximum            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Expected period of payment to be received       1 year    
CRG Servicing LLC            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Loan borrowed   $ 100,000,000.0   $ 75,000,000.0 $ 75,000,000.0  
Principal amount including interest paid in kind       $ 178,200,000    
Debt maturity date   Dec. 31, 2023        
HEPLISAV-B?            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Minimum age approved for vaccine prevention of infection caused       18 years