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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Revenues:        
Total revenues $ 8,301 $ 1,254 $ 14,074 $ 1,419
Operating expenses:        
Cost of sales - amortization of intangible assets 2,300 2,300 4,570 4,715
Research and development 16,196 16,273 37,402 35,239
Selling, general and administrative 17,861 15,653 36,209 32,544
Restructuring 8,777   8,777  
Total operating expenses 47,272 39,401 90,899 77,880
Loss from operations (38,971) (38,147) (76,825) (76,461)
Other income (expense):        
Interest income 979 1,153 1,714 1,893
Interest expense (4,598) (2,691) (7,332) (3,852)
Other (expense) income, net (123) 241 58 18
Net loss $ (42,713) $ (39,444) $ (82,385) $ (78,402)
Basic and diluted net loss per share $ (0.66) $ (0.63) $ (1.28) $ (1.26)
Weighted average shares used to compute basic and diluted net loss per share 65,088 62,346 64,436 62,047
Product        
Revenues:        
Total revenues $ 8,301 $ 1,254 $ 13,928 $ 1,419
Operating expenses:        
Cost of sales - product 2,141 5,177 3,941 5,382
Cost of sales - amortization of intangible assets $ 2,297 $ 2,298 4,570 $ 4,715
Collaboration Revenue        
Revenues:        
Total revenues     $ 146