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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2017 $ 199,549 $ 62 $ 1,107,693 $ (881) $ (907,325)
Beginning Balances (in shares) at Dec. 31, 2017   61,533      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (549) $ 1 (550)    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   1,017      
Issuance of common stock under Employee Stock Purchase Plan 255   255    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   58      
Stock compensation expense 11,089   11,089    
Total other comprehensive income (loss) (629)     (629)  
Net loss (78,402)       (78,402)
Ending Balances at Jun. 30, 2018 131,313 $ 63 1,118,487 (1,510) (985,727)
Ending Balances (in shares) at Jun. 30, 2018   62,608      
Beginning Balances at Mar. 31, 2018 165,887 $ 62 1,112,321 (213) (946,283)
Beginning Balances (in shares) at Mar. 31, 2018   62,254      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (123) $ 1 (124)    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   354      
Stock compensation expense 6,290   6,290    
Total other comprehensive income (loss) (1,297)     (1,297)  
Net loss (39,444)       (39,444)
Ending Balances at Jun. 30, 2018 131,313 $ 63 1,118,487 (1,510) (985,727)
Ending Balances (in shares) at Jun. 30, 2018   62,608      
Beginning Balances at Dec. 31, 2018 63,065 $ 63 1,131,241 (2,015) (1,066,224)
Beginning Balances (in shares) at Dec. 31, 2018   62,862      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 1   1    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   831      
Issuance of common stock under Employee Stock Purchase Plan 407   407    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   75      
Issuance of common stock, net of issuance costs 13,949 $ 2 13,947    
Issuance of common stock, net of issuance costs (in shares)   1,387      
Stock compensation expense 15,519   15,519    
Total other comprehensive income (loss) 32     32  
Net loss (82,385)       (82,385)
Ending Balances at Jun. 30, 2019 10,588 $ 65 1,161,115 (1,983) (1,148,609)
Ending Balances (in shares) at Jun. 30, 2019   65,155      
Beginning Balances at Mar. 31, 2019 43,159 $ 65 1,151,421 (2,431) (1,105,896)
Beginning Balances (in shares) at Mar. 31, 2019   65,020      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 19   19    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   91      
Issuance of common stock, net of issuance costs 326   326    
Issuance of common stock, net of issuance costs (in shares)   44      
Stock compensation expense 9,349   9,349    
Total other comprehensive income (loss) 448     448  
Net loss (42,713)       (42,713)
Ending Balances at Jun. 30, 2019 $ 10,588 $ 65 $ 1,161,115 $ (1,983) $ (1,148,609)
Ending Balances (in shares) at Jun. 30, 2019   65,155