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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) |  | 1 Months Ended | 9 Months Ended |
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May 23, 2019 Position | Aug. 31, 2019 USD ($) | Feb. 28, 2018 USD ($) | Sep. 30, 2019 USD ($) Segment | Jan. 01, 2019 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |
Number of positions reduced in global workforce | Position | 80 |  |  |  |
Percentage of reduction in global workforce | 36.00% |  |  |  |
Restructuring completion date |  |  |  | Dec. 31, 2019 |
Number of operating segment | Segment |  |  |  | 1 |
Cash, cash equivalents and marketable securities |  |  |  | $ 174,900,000 |
Principal amount including interest paid in kind |  |  | $ 179,100,000 | $ 179,100,000 |
Debt maturity date |  |  | Dec. 31, 2023 | Dec. 31, 2023 |
Proceeds from offering |  | $ 65,600,000 |  |  |
Right-of-use asset |  |  |  | $ 29,723,000 |
Operating lease, liability |  |  |  | 40,022,000 |
Inventory reserve |  |  |  | $ 0 |
ASC 842 |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |
Right-of-use asset |  |  |  |  | $ 34,800,000
Operating lease, liability |  |  |  |  | $ 37,100,000
Maximum |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |
Expected period of payment to be received |  |  |  | 1 year |
HEPLISAV-B? |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |
Minimum age approved for vaccine prevention of infection caused |  |  |  | 18 years |

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