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Organization and Summary of Significant Accounting Policies - Additional Information (Detail)		1 Months Ended		9 Months Ended
	May 23, 2019 Position	Aug. 31, 2019 USD ($)	Feb. 28, 2018 USD ($)	Sep. 30, 2019 USD ($) Segment	Jan. 01, 2019 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Number of positions reduced in global workforce | Position	80
Percentage of reduction in global workforce	36.00%
Restructuring completion date				Dec. 31, 2019
Number of operating segment | Segment				1
Cash, cash equivalents and marketable securities				$ 174,900,000
Principal amount including interest paid in kind			$ 179,100,000	$ 179,100,000
Debt maturity date			Dec. 31, 2023	Dec. 31, 2023
Proceeds from offering		$ 65,600,000
Right-of-use asset				$ 29,723,000
Operating lease, liability				40,022,000
Inventory reserve				$ 0
ASC 842
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Right-of-use asset					$ 34,800,000
Operating lease, liability					$ 37,100,000
Maximum
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Expected period of payment to be received				1 year
HEPLISAV-B?
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Minimum age approved for vaccine prevention of infection caused				18 years

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