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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Series B Convertible Preferred Stock
Common Stock
Preferred Stock
Preferred Stock
Series B Convertible Preferred Stock
Additional Paid-in Capital
Additional Paid-in Capital
Series B Convertible Preferred Stock
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2017 $ 199,549   $ 62     $ 1,107,693   $ (881) $ (907,325)
Beginning Balances (in shares) at Dec. 31, 2017     61,533            
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (529)   $ 1     (530)      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)     1,033            
Issuance of common stock under Employee Stock Purchase Plan 594         594      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     125            
Stock compensation expense 17,135         17,135      
Total other comprehensive loss (806)             (806)  
Net loss (118,930)               (118,930)
Ending Balances at Sep. 30, 2018 97,013   $ 63     1,124,892   (1,687) (1,026,255)
Ending Balances (in shares) at Sep. 30, 2018     62,691            
Beginning Balances at Jun. 30, 2018 131,313   $ 63     1,118,487   (1,510) (985,727)
Beginning Balances (in shares) at Jun. 30, 2018     62,608            
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 20         20      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)     16            
Issuance of common stock under Employee Stock Purchase Plan 339         339      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     67            
Stock compensation expense 6,046         6,046      
Total other comprehensive loss (177)             (177)  
Net loss (40,528)               (40,528)
Ending Balances at Sep. 30, 2018 97,013   $ 63     1,124,892   (1,687) (1,026,255)
Ending Balances (in shares) at Sep. 30, 2018     62,691            
Beginning Balances at Dec. 31, 2018 63,065   $ 63     1,131,241   (2,015) (1,066,224)
Beginning Balances (in shares) at Dec. 31, 2018     62,862            
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 2   $ 1     1      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)     969            
Issuance of common stock under Employee Stock Purchase Plan 565         565      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     122            
Issuance of common stock and preferred stock, net of issuance costs 60,113 $ 12,061 $ 20     60,093 $ 12,061    
Issuance of common stock and preferred stock, net of issuance costs (in shares)     19,912   5        
Stock compensation expense 20,267         20,267      
Total other comprehensive loss (1,073)             (1,073)  
Net loss (115,844)               (115,844)
Ending Balances at Sep. 30, 2019 39,156   $ 84     1,224,228   (3,088) (1,182,068)
Ending Balances (in shares) at Sep. 30, 2019     83,865 5          
Beginning Balances at Jun. 30, 2019 10,588   $ 65     1,161,115   (1,983) (1,148,609)
Beginning Balances (in shares) at Jun. 30, 2019     65,155            
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)     138            
Issuance of common stock under Employee Stock Purchase Plan 158         158      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     47            
Issuance of common stock and preferred stock, net of issuance costs 46,165 $ 12,061 $ 19     46,146 $ 12,061    
Issuance of common stock and preferred stock, net of issuance costs (in shares)     18,525   5        
Stock compensation expense 4,748         4,748      
Total other comprehensive loss (1,105)             (1,105)  
Net loss (33,459)               (33,459)
Ending Balances at Sep. 30, 2019 $ 39,156   $ 84     $ 1,224,228   $ (3,088) $ (1,182,068)
Ending Balances (in shares) at Sep. 30, 2019     83,865 5