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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Operating activities    
Net loss $ (115,844) $ (118,930)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 7,838 2,511
Amortization of right-of-use assets 2,742  
Accretion of discounts on marketable securities (1,293) (1,146)
Revaluation of warrant liability 234  
Stock compensation expense 20,267 17,135
Cost of sales - amortization of intangible assets 6,894 8,538
Non-cash interest expense 3,533 1,944
Tenant improvements provided by the landlord 6,639  
Changes in operating assets and liabilities:    
Accounts and other receivables, net (5,118) (653)
Inventories, net (20,334) (12,140)
Prepaid expenses and other current assets 391 (907)
Other assets 1,467 (2,564)
Accounts payable 3,035 2,377
Lease liabilities (1,340)  
Accrued liabilities and other liabilities (7,351) 6,164
Net cash used in operating activities (98,240) (97,671)
Investing activities    
Acquisition of technology licenses (7,000) (11,000)
Purchases of marketable securities (181,148) (187,808)
Proceeds from maturities of marketable securities 141,085 212,700
Purchases of property and equipment, net (20,570) (2,838)
Net cash (used in) provided by investing activities (67,633) 11,054
Financing activities    
Proceeds from long-term debt, net 74,250 99,000
Proceeds from issuance of common stock, net 65,948  
Proceeds from issuance of preferred stock, net 13,586  
Proceeds (tax withholding) from exercise of stock options and restricted stock awards, net 2 (529)
Proceeds from Employee Stock Purchase Plan 565 594
Net cash provided by financing activities 154,351 99,065
Effect of exchange rate changes on cash, cash equivalents and restricted cash (529) (327)
Net (decrease) increase in cash, cash equivalents and restricted cash (12,051) 12,121
Cash, cash equivalents and restricted cash at beginning of period 49,967 27,213
Cash, cash equivalents and restricted cash at end of period 37,916 39,334
Supplemental disclosure of cash flow information    
Cash paid during the period for interest 8,715 4,643
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 9,418 199
Non-cash acquisition of technology license   12,773
Purchases of property and equipment, not yet paid 3,135 $ 759
Proceeds allocated to warrant liability at issuance 7,360  
Right-of-use assets obtained in exchange for operating lease liabilities $ 39,104