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v3.20.1

Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands | Total | Offering | Offering Series B Convertible Preferred Stock | Common Stock | Common Stock Offering | Preferred Stock | Preferred Stock Offering Series B Convertible Preferred Stock | Additional Paid-in Capital | Additional Paid-in Capital Offering | Additional Paid-in Capital Offering Series B Convertible Preferred Stock | Accumulated Other Comprehensive (Loss) Income | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning Balances at Dec. 31, 2016 | $ 89,201 |  |  | $ 39 |  |  |  | $ 904,957 |  |  | $ (3,624) | $ (812,171)
Beginning Balances (in shares) at Dec. 31, 2016 |  |  |  | 38,599 |  |  |  |  |  |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net | 1,613 |  |  |  |  |  |  | 1,613 |  |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares) |  |  |  | 262 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 293 |  |  |  |  |  |  | 293 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  | 84 |  |  |  |  |  |  |  |
Issuance of common stock and preferred stock, net of issuance costs | 185,936 |  |  | $ 23 |  |  |  | 185,913 |  |  |  |
Issuance of common stock and preferred stock, net of issuance costs (in shares) |  |  |  | 22,588 |  |  |  |  |  |  |  |
Stock compensation expense | 14,917 |  |  |  |  |  |  | 14,917 |  |  |  |
Total other comprehensive income (loss) | 2,743 |  |  |  |  |  |  |  |  |  | 2,743 |
Net loss | (95,154) |  |  |  |  |  |  |  |  |  |  | (95,154)
Ending Balances at Dec. 31, 2017 | 199,549 |  |  | $ 62 |  |  |  | 1,107,693 |  |  | (881) | (907,325)
Ending Balances (in shares) at Dec. 31, 2017 |  |  |  | 61,533 |  |  |  |  |  |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net | (523) |  |  | $ 1 |  |  |  | (524) |  |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares) |  |  |  | 1,204 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 594 |  |  |  |  |  |  | 594 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  | 125 |  |  |  |  |  |  |  |
Stock compensation expense | 23,478 |  |  |  |  |  |  | 23,478 |  |  |  |
Total other comprehensive income (loss) | (1,134) |  |  |  |  |  |  |  |  |  | (1,134) |
Net loss | (158,899) |  |  |  |  |  |  |  |  |  |  | (158,899)
Ending Balances at Dec. 31, 2018 | 63,065 |  |  | $ 63 |  |  |  | 1,131,241 |  |  | (2,015) | (1,066,224)
Ending Balances (in shares) at Dec. 31, 2018 |  |  |  | 62,862 |  |  |  |  |  |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net | 2 |  |  | $ 1 |  |  |  | 1 |  |  |  |
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares) |  |  |  | 975 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 565 |  |  |  |  |  |  | 565 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  | 122 |  |  |  |  |  |  |  |
Issuance of common stock and preferred stock, net of issuance costs |  | $ 60,113 | $ 12,061 |  | $ 20 |  |  |  | $ 60,093 | $ 12,061 |  |
Issuance of common stock and preferred stock, net of issuance costs (in shares) |  |  |  |  | 19,912 |  | 5 |  |  |  |  |
Stock compensation expense | 25,456 |  |  |  |  |  |  | 25,456 |  |  |  |
Total other comprehensive income (loss) | (372) |  |  |  |  |  |  |  |  |  | (372) |
Net loss | (152,600) |  |  |  |  |  |  |  |  |  |  | (152,600)
Ending Balances at Dec. 31, 2019 | $ 8,290 |  |  | $ 84 |  |  |  | $ 1,229,417 |  |  | $ (2,387) | $ (1,218,824)
Ending Balances (in shares) at Dec. 31, 2019 |  |  |  | 83,871 |  | 5 |  |  |  |  |  |

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