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Component of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2019 | Dec. 31, 2018
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carry forwards | $ 207,385 | $ 178,730
Research tax credit carry forwards | 27,883 | 34,064
Accruals and reserves | 17,312 | 10,137
Capitalized research costs | 256 | 943
Other | 2,437 | 1,147
Total deferred tax assets | 255,273 | 225,021
Less valuation allowance | (247,092) | (224,746)
Net deferred tax assets | 8,181 | 275
Deferred tax liabilities: |  |
Fixed assets | (275) | (275)
Operating lease right-of-use assets | (7,906) |
Total deferred tax liabilities | $ (8,181) | $ (275)

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