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Collaborative Research, Development and License Agreements - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 8 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Feb. 29, 2020 USD ($) | Feb. 28, 2019 USD ($) | Jul. 31, 2018 USD ($) | Feb. 28, 2018 USD ($) Installment | Jan. 31, 2018 USD ($) | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Jul. 31, 2018 | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  |  |  |  | $ 10,570,000 | $ 10,575,000 | $ 8,301,000 | $ 5,773,000 | $ 5,318,000 | $ 1,461,000 | $ 1,254,000 | $ 165,000 |  | $ 35,219,000 | $ 8,198,000 | $ 327,000
Intangible assets, net |  |  |  |  |  | 2,500,000 |  |  |  | $ 11,717,000 |  |  |  |  | 2,500,000 | 11,717,000 |
Collaboration Revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 143,000 | 1,386,000 |
Serum Institute of India Pvt. Ltd. | Collaboration Revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 | 1,400,000 | $ 0
Merck, Sharp & Dohme Corp. | Sublicense Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate amount payable to acquire intangible assets |  |  |  | $ 21,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Number of installments | Installment |  |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |
Payment upon obligation |  | $ 7,000,000.0 |  | $ 7,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Intangible assets |  |  |  | $ 19,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Intangible assets, net |  |  |  |  |  | $ 2,500,000 |  |  |  |  |  |  |  |  | $ 2,500,000 |  |
Merck, Sharp & Dohme Corp. | Sublicense Agreement | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment upon obligation | $ 7,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
GlaxoSmithKline Biologicals SA |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of royalty on net sales |  |  |  |  |  |  |  |  |  |  |  |  |  | 13.00% |  |  |
GlaxoSmithKline Biologicals SA | License |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment upon obligation |  |  | $ 1,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
GlaxoSmithKline Biologicals SA | Royalty |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalties in cost of sales |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 200,000 |
Coley Pharmaceutical Group, Inc. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Agreement termination date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2018-02 |
Amortization of intangible assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,500,000 |
Coley Pharmaceutical Group, Inc. | Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment upon obligation |  |  |  |  | $ 2,500,000 |  |  |  |  |  |  |  |  |  |  |  |

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