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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Revenues:      
Total revenues $ 35,219 $ 8,198 $ 327
Operating expenses:      
Cost of sales - amortization of intangible assets 9,217 10,862 1,194
Research and development 62,331 74,951 64,988
Selling, general and administrative 74,986 64,770 27,367
Restructuring 13,356   2,783
Total operating expenses 170,062 161,517 96,332
Loss from operations (134,843) (153,319) (96,005)
Other income (expense):      
Interest income 3,370 3,828 1,337
Interest expense (16,977) (9,338)  
Sublease income 2,619    
Change in fair value of warrant liability (7,500)    
Other income (expense), net 731 (70) (486)
Net loss (152,600) (158,899) (95,154)
Preferred stock deemed dividend (3,267)    
Net loss allocable to common stockholders $ (155,867) $ (158,899) $ (95,154)
Net loss per share allocable to common stockholders - basic and diluted $ (2.16) $ (2.55) $ (1.81)
Weighted average shares used to compute basic and diluted net loss per share allocable to common stockholders 72,024 62,362 52,613
Product      
Revenues:      
Total revenues $ 34,644 $ 6,812  
Operating expenses:      
Cost of sales - product 10,172 10,934  
Cost of sales - amortization of intangible assets 9,217 10,862 $ 1,194
Collaboration Revenue      
Revenues:      
Total revenues 143 $ 1,386  
Other Revenue      
Revenues:      
Total revenues $ 432   $ 327