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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2019

Income Tax Disclosure [Abstract]

Component of Consolidated (Loss) Income Before Provision for Income Taxes

Consolidated (loss) income before provision for income taxes consisted of the following (in thousands):

		Year Ended December 31,
		2019				2018				2017
U.S.		$	(154,605	)		$	(160,032	)		$	(95,898	)
Non U.S.			2,005				1,133				744
Total		$	(152,600	)		$	(158,899	)		$	(95,154	)

Difference Between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate

The difference between the consolidated income tax benefit and the amount computed by applying the federal statutory income tax rate to the consolidated loss before income taxes was as follows (in thousands):

		Year Ended December 31,
		2019				2018				2017
Income tax benefit at federal statutory rate		$	(32,046	)		$	(33,366	)		$	(32,352	)
State tax			(3,153	)			(5,591	)			(4,482	)
Business credits			(1,757	)			(3,065	)			(1,960	)
Uncertain tax positions			5,426				-				-
Deferred compensation charges			4,600				(1,165	)			3,823
Change in valuation allowance			22,715				43,134				(109,165	)
Rate change			-				-				86,943
Net operating loss and tax credit limitation			-				-				56,962
Section 162(m) limitation			2,439				-				-
Mark-to-market of warrants			1,575				-				-
Other			201				53				231
Total income tax expense		$	-			$	-			$	-

Component of Deferred Tax Assets and Liabilities

Deferred tax assets and liabilities consisted of the following (in thousands): 

		December 31,
		2019				2018
Deferred tax assets:
Net operating loss carry forwards		$	207,385			$	178,730
Research tax credit carry forwards			27,883				34,064
Accruals and reserves			17,312				10,137
Capitalized research costs			256				943
Other			2,437				1,147
Total deferred tax assets			255,273				225,021
Less valuation allowance			(247,092	)			(224,746	)
Net deferred tax assets			8,181				275
Deferred tax liabilities:
Fixed assets			(275	)			(275	)
Operating lease right-of-use assets			(7,906	)			-
Total deferred tax liabilities			(8,181	)			(275	)
Net deferred tax assets		$	-			$	-

Schedule of Unrecognized Tax Benefits

The following table summarizes the activity related to our unrecognized tax benefits:

Balance at December 31, 2018		$	(1,229	)
Tax positions related to the current year
Additions			(439	)
Reductions			-
Tax positions related to the prior year
Additions			(8,654	)
Reductions			-
Balance at December 31, 2019		$	(10,322	)

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure of the change in unrecognized tax benefits.

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