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Commitments and Contingencies - Additional Information (Detail) € in Millions				1 Months Ended					12 Months Ended
	Jul. 31, 2019 USD ($) ft²	Sep. 17, 2018 USD ($) ft²	Feb. 20, 2018 USD ($)	Feb. 29, 2020 USD ($)	Jul. 31, 2019 USD ($) ft²	Feb. 28, 2019 USD ($)	Feb. 28, 2018 USD ($)	Nov. 30, 2009 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2019 EUR (€)	Mar. 29, 2019 USD ($)	Dec. 31, 2018 EUR (€)	Dec. 31, 2004 EUR (€)
Loss Contingencies [Line Items]
Tenant improvement allowance									$ (6,999,000)
Sublease income									2,619,000
Cash paid for amounts included in the measurement of operating lease liabilities									$ 5,500,000
Operating lease, weighted average remaining lease term									9 years 8 months 12 days		9 years 8 months 12 days
Operating lease, weighted average discount rate									10.10%		10.10%
Non-cancelable purchase and other commitments									$ 7,600,000
Symphony Dynamo Holdings LLC
Loss Contingencies [Line Items]
License arrangement contingent consideration percentage								50.00%
License arrangement upfront payment								$ 50,000,000
Milestone payments									0	$ 0
Deutsche Bank Securities
Loss Contingencies [Line Items]
Letter of credit pledged as security \| €														€ 0.2
Collateralized certificate of deposit \| €											€ 0.2		€ 0.2
CRG Servicing LLC
Loss Contingencies [Line Items]
Maximum borrowing capacity			$ 175,000,000.0
Current borrowing capacity			$ 100,000,000.0									$ 75,000,000.0
Principal amount including interest paid in kind									178,600,000
Debt discount									1,400,000
Contractual obligation									187,200,000
Principal amount									175,000,000.0
Paid-in-kind interest									5,000,000.0
Backend facility fee									$ 7,200,000
Debt maturity date			Dec. 31, 2023						Dec. 31, 2023
Merck, Sharp & Dohme Corp. \| Sublicense Agreement
Loss Contingencies [Line Items]
Payment upon obligation						$ 7,000,000.0	$ 7,000,000.0
Merck, Sharp & Dohme Corp. \| Subsequent Event \| Sublicense Agreement
Loss Contingencies [Line Items]
Payment upon obligation				$ 7,000,000.0
Powell Street Sublease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²	23,976				23,976
Base rent per square feet	$ 3.90
Lease expiration date	Jun. 30, 2022
Option to extend									There is no option to extend the sublease term.
Existence of option to extend									false
Horton Street Master Lease
Loss Contingencies [Line Items]
Percentage of excess rent paid to landlord									50.00%		50.00%
Horton Street Master Lease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²		75,662
Base rent per square feet		$ 4.75
Operations commencement date		Apr. 01, 2019
Tenant improvement allowance		$ 7,000,000.0
Initial lease term		12 years
Lease option to extend		The Horton Street Master Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms
Renewal term of lease		5 years
Horton Street Master Lease \| Emeryville, California (Premises) \| Maximum
Loss Contingencies [Line Items]
Tenant improvement allowance		$ 8,300,000
Horton Street Sublease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²	75,662				75,662
Base rent per square feet					$ 5.50
Lease expiration date					Mar. 31, 2031
Option to extend					The Subtenant has no option to extend the sublease term.
Existence of option to extend					false
Sublease income									$ 2,600,000
Horton Street Sublease \| Emeryville, California (Premises) \| Other Income (Expense)
Loss Contingencies [Line Items]
Sublease income									$ 2,600,000