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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Offering
Offering
Series B Convertible Preferred Stock
Common Stock
Common Stock
Offering
Preferred Stock
Preferred Stock
Offering
Series B Convertible Preferred Stock
Additional Paid-in Capital
Additional Paid-in Capital
Offering
Additional Paid-in Capital
Offering
Series B Convertible Preferred Stock
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2016 $ 89,201     $ 39       $ 904,957     $ (3,624) $ (812,171)
Beginning Balances (in shares) at Dec. 31, 2016       38,599                
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 1,613             1,613        
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)       262                
Issuance of common stock under Employee Stock Purchase Plan 293             293        
Issuance of common stock under Employee Stock Purchase Plan (in shares)       84                
Issuance of common stock and preferred stock, net of issuance costs 185,936     $ 23       185,913        
Issuance of common stock and preferred stock, net of issuance costs (in shares)       22,588                
Stock compensation expense 14,917             14,917        
Total other comprehensive income (loss) 2,743                   2,743  
Net loss (95,154)                     (95,154)
Ending Balances at Dec. 31, 2017 199,549     $ 62       1,107,693     (881) (907,325)
Ending Balances (in shares) at Dec. 31, 2017       61,533                
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (523)     $ 1       (524)        
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)       1,204                
Issuance of common stock under Employee Stock Purchase Plan 594             594        
Issuance of common stock under Employee Stock Purchase Plan (in shares)       125                
Stock compensation expense 23,478             23,478        
Total other comprehensive income (loss) (1,134)                   (1,134)  
Net loss (158,899)                     (158,899)
Ending Balances at Dec. 31, 2018 63,065     $ 63       1,131,241     (2,015) (1,066,224)
Ending Balances (in shares) at Dec. 31, 2018       62,862                
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 2     $ 1       1        
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)       975                
Issuance of common stock under Employee Stock Purchase Plan 565             565        
Issuance of common stock under Employee Stock Purchase Plan (in shares)       122                
Issuance of common stock and preferred stock, net of issuance costs   $ 60,113 $ 12,061   $ 20       $ 60,093 $ 12,061    
Issuance of common stock and preferred stock, net of issuance costs (in shares)         19,912   5          
Stock compensation expense 25,456             25,456        
Total other comprehensive income (loss) (372)                   (372)  
Net loss (152,600)                     (152,600)
Ending Balances at Dec. 31, 2019 $ 8,290     $ 84       $ 1,229,417     $ (2,387) $ (1,218,824)
Ending Balances (in shares) at Dec. 31, 2019       83,871   5