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Collaborative Research, Development and License Agreements - Additional Information (Detail)	1 Months Ended					3 Months Ended								8 Months Ended	12 Months Ended
	Feb. 29, 2020 USD ($)	Feb. 28, 2019 USD ($)	Jul. 31, 2018 USD ($)	Feb. 28, 2018 USD ($) Installment	Jan. 31, 2018 USD ($)	Dec. 31, 2019 USD ($)	Sep. 30, 2019 USD ($)	Jun. 30, 2019 USD ($)	Mar. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Sep. 30, 2018 USD ($)	Jun. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Jul. 31, 2018	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue recognized						$ 10,570,000	$ 10,575,000	$ 8,301,000	$ 5,773,000	$ 5,318,000	$ 1,461,000	$ 1,254,000	$ 165,000		$ 35,219,000	$ 8,198,000	$ 327,000
Intangible assets, net						2,500,000				$ 11,717,000					2,500,000	11,717,000
Collaboration Revenue
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue recognized															143,000	1,386,000
Serum Institute of India Pvt. Ltd. | Collaboration Revenue
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue recognized															100,000	1,400,000	$ 0
Merck, Sharp & Dohme Corp. | Sublicense Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Aggregate amount payable to acquire intangible assets				$ 21,000,000.0
Number of installments | Installment				3
Payment upon obligation		$ 7,000,000.0		$ 7,000,000.0
Intangible assets				$ 19,800,000
Intangible assets, net						$ 2,500,000									$ 2,500,000
Merck, Sharp & Dohme Corp. | Sublicense Agreement | Subsequent Event
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Payment upon obligation	$ 7,000,000.0
GlaxoSmithKline Biologicals SA
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Percentage of royalty on net sales														13.00%
GlaxoSmithKline Biologicals SA | License
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Payment upon obligation			$ 1,500,000
GlaxoSmithKline Biologicals SA | Royalty
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Royalties in cost of sales																$ 200,000
Coley Pharmaceutical Group, Inc.
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Agreement termination date																2018-02
Amortization of intangible assets																$ 2,500,000
Coley Pharmaceutical Group, Inc. | Intangible Assets
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Payment upon obligation					$ 2,500,000

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