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Common Stock, Preferred Stock and Warrants - Additional Information (Detail) - USD ($)
 1 Months Ended 3 Months Ended
Nov. 03, 2017
May 01, 2020
Aug. 31, 2019
Mar. 31, 2020
Mar. 31, 2019
Mar. 11, 2020
Dec. 31, 2019
Aug. 12, 2019
Class Of Stock [Line Items]                
Common stock, shares outstanding       87,599,440     83,871,000  
Issuance of common stock and preferred stock (in shares)     18,525,000          
Common stock, par value     $ 0.001 $ 0.001     $ 0.001  
Preferred stock, par value       $ 0.001     $ 0.001  
Net cash proceeds received       $ 14,229,000 $ 13,623,000      
Decrease in estimated fair value of warrant liability as gain       $ (8,610,000)        
Common Stock                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)       2,909,000 1,343,000      
Warrants                
Class Of Stock [Line Items]                
Fair value of derivative liability       $ 6,300,000       $ 7,400,000
Warrants | Other Income, Net                
Class Of Stock [Line Items]                
Decrease in estimated fair value of warrant liability as gain       $ 8,600,000        
Bain Life Sciences                
Class Of Stock [Line Items]                
Net cash proceeds received from issuance or sale of equity     $ 35,000,000.0          
Bain Capital Life Sciences Fund, L.P                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)     6,826,266          
Number of common stock allowed to purchase     2,645,566          
Net cash proceeds received from issuance or sale of equity     $ 31,700,000          
BCIP Life Sciences Associates, L.P                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)     698,734          
Number of common stock allowed to purchase     270,684          
Net cash proceeds received from issuance or sale of equity     $ 3,200,000          
Offering                
Class Of Stock [Line Items]                
Number of common stock allowed to purchase     0.25          
Combined price of common stock and warrant     $ 3.00          
Net cash proceeds received from issuance or sale of equity     $ 65,600,000          
Payment of issuance costs     $ 4,500,000          
2017 ATM Agreement                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)       2,908,875        
Net cash proceeds received       $ 14,200,000        
Remaining proceeds from common stock, under sales agreement       $ 104,000,000.0        
2017 ATM Agreement | Subsequent Event                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)   4,584,591            
Net cash proceeds received   $ 15,900,000            
Series B Convertible Preferred Stock                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)     4,840          
Preferred stock, par value     $ 0.001          
Preferred stock, shares outstanding       4,840     5,000  
Preferred stock deemed dividend       $ 3,300,000        
Series B Convertible Preferred Stock | Common Stock                
Class Of Stock [Line Items]                
Number of common stock allowed to purchase       1,000        
Series B Convertible Preferred Stock | Bain Capital Life Sciences Fund, L.P                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)     3,756          
Series B Convertible Preferred Stock | BCIP Life Sciences Associates, L.P                
Class Of Stock [Line Items]                
Issuance of common stock and preferred stock (in shares)     384          
Series B Convertible Preferred Stock | Offering                
Class Of Stock [Line Items]                
Number of common stock allowed to purchase     250          
Combined price of preferred stock and warrant     $ 3,000          
Series C Convertible Preferred Stock | Bain Life Sciences | Common Stock                
Class Of Stock [Line Items]                
Number of common stock allowed to purchase           1,000    
Conversion price per share           $ 4.50    
Maximum | Warrants                
Class Of Stock [Line Items]                
Percentage of common stock held not to exceed for warrant exercises       19.99%        
Maximum | Offering                
Class Of Stock [Line Items]                
Warrant issued     5,841,250          
Maximum | 2017 ATM Agreement                
Class Of Stock [Line Items]                
Common stock sales agreement aggregate sales proceeds $ 150,000,000              
Commission on gross sales proceeds of common stock 3.00%              
Maximum | Series B Convertible Preferred Stock                
Class Of Stock [Line Items]                
Percentage of common stock held not to exceed for warrant exercises       19.99%        
Minimum | Warrants                
Class Of Stock [Line Items]                
Percentage of common stock to be held for exercise of warrants       4.99%        
Minimum | Series B Convertible Preferred Stock                
Class Of Stock [Line Items]                
Percentage of common stock to be held for conversion       4.99%