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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Preferred Stock
Additional Paid-in Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2018 $ 63,065 $ 63   $ 1,131,241 $ (2,015) $ (1,066,224)
Beginning Balances (in shares) at Dec. 31, 2018   62,862,000        
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 1     1    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   831,000        
Issuance of common stock under Employee Stock Purchase Plan 407     407    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   75,000        
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 13,949 $ 2   13,947    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   1,387,000        
Stock compensation expense 15,519     15,519    
Total other comprehensive income 32       32  
Net loss (82,385)         (82,385)
Ending Balances at Jun. 30, 2019 10,588 $ 65   1,161,115 (1,983) (1,148,609)
Ending Balances (in shares) at Jun. 30, 2019   65,155,000        
Beginning Balances at Mar. 31, 2019 43,159 $ 65   1,151,421 (2,431) (1,105,896)
Beginning Balances (in shares) at Mar. 31, 2019   65,020,000        
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 19     19    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   91,000        
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 326     326    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   44,000        
Stock compensation expense 9,349     9,349    
Total other comprehensive income 448       448  
Net loss (42,713)         (42,713)
Ending Balances at Jun. 30, 2019 10,588 $ 65   1,161,115 (1,983) (1,148,609)
Ending Balances (in shares) at Jun. 30, 2019   65,155,000        
Beginning Balances at Dec. 31, 2019 8,290 $ 84   1,229,417 (2,387) (1,218,824)
Beginning Balances (in shares) at Dec. 31, 2019   83,871,000 5,000      
Conversion of preferred stock 1 $ 1        
Stock Issued During Period, Shares, Conversion of Convertible Securities   700,000        
Stock Redeemed During Period, Shares, Conversion of Convertible Securities (in shares)     (1,000)      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 13 $ 1   12    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   735,000        
Issuance of common stock under Employee Stock Purchase Plan 311     311    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   91,000        
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 107,696 $ 23   107,673    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   24,106,000        
Stock compensation expense 5,866     5,866    
Total other comprehensive income 292       292  
Net loss (64,174)         (64,174)
Ending Balances at Jun. 30, 2020 58,295 $ 109   1,343,279 (2,095) (1,282,998)
Ending Balances (in shares) at Jun. 30, 2020   109,503,000 4,000      
Beginning Balances at Mar. 31, 2020 11,824 $ 88   1,245,730 (2,575) (1,231,419)
Beginning Balances (in shares) at Mar. 31, 2020   87,599,000 5,000      
Conversion of preferred stock 1 $ 1        
Stock Issued During Period, Shares, Conversion of Convertible Securities   700,000        
Stock Redeemed During Period, Shares, Conversion of Convertible Securities (in shares)     (1,000)      
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net 14     14    
Issuance (withholding) of common stock upon exercise of stock options and restricted stock awards, net (in shares)   7,000        
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 93,467 $ 20   93,447    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   21,197,000        
Stock compensation expense 4,088     4,088    
Total other comprehensive income 480       480  
Net loss (51,579)         (51,579)
Ending Balances at Jun. 30, 2020 $ 58,295 $ 109   $ 1,343,279 $ (2,095) $ (1,282,998)
Ending Balances (in shares) at Jun. 30, 2020   109,503,000 4,000