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Opearting lease rent area.

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Commitments and Contingencies - Additional Information (Detail) € in Millions			1 Months Ended		3 Months Ended			9 Months Ended
	Sep. 17, 2018 USD ($) ft²	Feb. 20, 2018 USD ($)	Jul. 31, 2019 USD ($) ft²	Nov. 30, 2009 USD ($)	Sep. 30, 2020 USD ($)	Mar. 31, 2020	Sep. 30, 2019 USD ($)	Sep. 30, 2020 USD ($)	Sep. 30, 2019 USD ($)	Sep. 30, 2020 EUR (€)	Dec. 31, 2019 USD ($)	Mar. 29, 2019 USD ($)	Dec. 31, 2004 EUR (€)
Loss Contingencies [Line Items]
Tenant improvement allowance								$ (908,000)	$ (6,639,000)
Sublease income					$ 1,926,000		$ 891,000	5,779,000	891,000
Cash paid for amounts included in the measurement of operating lease liabilities								5,100,000	3,800,000
Principal amount including interest paid in kind					180,900,000			$ 180,900,000
Debt maturity date								Dec. 31, 2023
Non-cancelable purchase and other commitments					28,100,000			$ 28,100,000
Letter of credit pledged as security \| €													€ 0.2
Collateralized certificate of deposit \| €										€ 0.2
Liability under agreement					284,111,000			284,111,000			$ 270,778,000
Symphony Dynamo Holdings Llc
Loss Contingencies [Line Items]
License arrangement contingent consideration percentage				50.00%
License arrangement upfront payment				$ 50,000,000
Symphony Dynamo Holdings Llc \| Asset Purchase Agreement
Loss Contingencies [Line Items]
Liability under agreement					$ 0			$ 0
Contingent precommencialization milestone payments percentage					50.00%			50.00%		50.00%
CRG Servicing LLC
Loss Contingencies [Line Items]
Maximum borrowing capacity		$ 175,000,000.0
Current borrowing capacity		$ 100,000,000.0										$ 75,000,000.0
Principal amount including interest paid in kind					$ 180,900,000			$ 180,900,000
Debt maturity date		Dec. 31, 2023						Dec. 31, 2023
Powell Street Sublease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²			23,976
Base rent per square feet			$ 3.90
Lease expiration date			Jun. 30, 2022
Option to extend						There is no option to extend the sublease term
Existence of option to extend						false
Horton Street Master Lease
Loss Contingencies [Line Items]
Percentage of excess rent paid to landlord					50.00%			50.00%		50.00%
Horton Street Master Lease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²	75,662
Base rent per square feet	$ 4.75
Operations commencement date	Apr. 01, 2019
Tenant improvement allowance	$ 7,900,000
Initial lease term	12 years
Lease option to extend	The Horton Street Master Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms.
Renewal term of lease	5 years
Horton Street Master Lease \| Emeryville, California (Premises) \| Maximum
Loss Contingencies [Line Items]
Tenant improvement allowance	$ 8,300,000
Horton Street Sublease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²			75,662
Base rent per square feet			$ 5.50
Lease expiration date			Mar. 31, 2031
Option to extend			The Subtenant has no option to extend the sublease term.
Existence of option to extend			false
Horton Street Sublease \| Emeryville, California (Premises) \| Other Income (Expense)
Loss Contingencies [Line Items]
Sublease income					$ 1,900,000		$ 900,000	$ 5,800,000	$ 900,000