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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Series B Convertible Preferred Stock
Common Stock
Preferred Stock
Preferred Stock
Series B Convertible Preferred Stock
Additional Paid-in Capital
Additional Paid-in Capital
Series B Convertible Preferred Stock
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2018 $ 63,065   $ 63     $ 1,131,241   $ (2,015) $ (1,066,224)
Beginning Balances (in shares) at Dec. 31, 2018     62,862,000            
Issuance of common stock upon exercise of stock options and restricted stock awards, net 2   $ 1     1      
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)     969,000            
Issuance of common stock under Employee Stock Purchase Plan 565         565      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     122,000            
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 60,113 $ 12,061 $ 20     60,093 $ 12,061    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)     19,912,000   5,000        
Stock compensation expense 20,267         20,267      
Total other comprehensive income (Loss) (1,073)             (1,073)  
Net income (loss) (115,844)               (115,844)
Ending Balances at Sep. 30, 2019 39,156   $ 84     1,224,228   (3,088) (1,182,068)
Ending Balances (in shares) at Sep. 30, 2019     83,865,000 5,000          
Beginning Balances at Jun. 30, 2019 10,588   $ 65     1,161,115   (1,983) (1,148,609)
Beginning Balances (in shares) at Jun. 30, 2019     65,155,000            
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)     138,000            
Issuance of common stock under Employee Stock Purchase Plan 158         158      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     47,000            
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 46,165 $ 12,061 $ 19     46,146 $ 12,061    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)     18,525,000   5,000        
Stock compensation expense 4,748         4,748      
Total other comprehensive income (Loss) (1,105)             (1,105)  
Net income (loss) (33,459)               (33,459)
Ending Balances at Sep. 30, 2019 39,156   $ 84     1,224,228   (3,088) (1,182,068)
Ending Balances (in shares) at Sep. 30, 2019     83,865,000 5,000          
Beginning Balances at Dec. 31, 2019 8,290   $ 84     1,229,417   (2,387) (1,218,824)
Beginning Balances (in shares) at Dec. 31, 2019     83,871,000 5,000          
Conversion of preferred stock 1   $ 1            
Stock Issued During Period, Shares, Conversion of Convertible Securities     700,000            
Stock Redeemed During Period, Shares, Conversion of Convertible Securities (in shares)       (1,000)          
Issuance of common stock upon exercise of stock options and restricted stock awards, net 224   $ 1     223      
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)     1,192,000            
Issuance of common stock under Employee Stock Purchase Plan 672         672      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     195,000            
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 108,537   $ 24     108,513      
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)     24,215,000            
Stock compensation expense 9,968         9,968      
Total other comprehensive income (Loss) 1,365             1,365  
Net income (loss) (59,773)               (59,773)
Ending Balances at Sep. 30, 2020 69,284   $ 110     1,348,793   (1,022) (1,278,597)
Ending Balances (in shares) at Sep. 30, 2020     110,173,000 4,000          
Beginning Balances at Jun. 30, 2020 58,295   $ 109     1,343,279   (2,095) (1,282,998)
Beginning Balances (in shares) at Jun. 30, 2020     109,503,000 4,000          
Issuance of common stock upon exercise of stock options and restricted stock awards, net 213   $ 1     212      
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)     457,000            
Issuance of common stock under Employee Stock Purchase Plan 361         361      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     104,000            
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 839         839      
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)     109,000            
Stock compensation expense 4,102         4,102      
Total other comprehensive income (Loss) 1,073             1,073  
Net income (loss) 4,401               4,401
Ending Balances at Sep. 30, 2020 $ 69,284   $ 110     $ 1,348,793   $ (1,022) $ (1,278,597)
Ending Balances (in shares) at Sep. 30, 2020     110,173,000 4,000