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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenues:      
Total revenues $ 46,551 $ 35,219 $ 8,198
Operating expenses:      
Cost of sales - amortization of intangible assets 2,500 9,217 10,862
Research and development 28,607 62,331 74,951
Selling, general and administrative 79,256 74,986 64,770
Restructuring   13,356  
Total operating expenses 114,922 170,062 161,517
Gain on sale of assets (6,851)    
Loss from operations (68,371) (134,843) (153,319)
Other income (expense):      
Interest income 1,260 3,370 3,828
Interest expense (19,062) (16,977) (9,338)
Sublease income 7,706 2,619  
Change in fair value of warrant liability (Note 14) 4,124 (7,500)  
Other (897) 731 (70)
Net loss (75,240) (152,600) (158,899)
Preferred stock deemed dividend   (3,267)  
Net loss allocable to common stockholders $ (75,240) $ (155,867) $ (158,899)
Basic net loss per share allocable to common stockholders $ (0.75) $ (2.16) $ (2.55)
Weighted average shares used to compute basic net loss per share allocable to common stockholders 100,753 72,024 62,362
Diluted net loss per share allocable to common stockholders $ (0.78) $ (2.16) $ (2.55)
Weighted average shares used to compute diluted net loss per share allocable to common stockholders 101,504 72,024 62,362
Product      
Revenues:      
Total revenues $ 39,307 $ 34,644 $ 6,812
Operating expenses:      
Cost of sales - product 11,410 10,172 10,934
Cost of sales - amortization of intangible assets 2,500 9,217 10,862
Other Revenue      
Revenues:      
Total revenues $ 7,244 $ 575 $ 1,386