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Intangible Assets, Net - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Finite Lived Intangible Assets [Line Items]
Cost of sales - amortization of intangible assets	$ 2,500,000	$ 9,217,000	$ 10,862,000
Impairment of intangible assets	0	0
Selling, general and administrative	79,256,000	74,986,000	$ 64,770,000
Asset Purchase Agreement
Finite Lived Intangible Assets [Line Items]
Upfront payment	5,000,000
Upfront payment receivable	4,000,000
Additional milestone payments receivable	250,000,000
Gain on sale of assets	6,900,000
Selling, general and administrative	2,500,000
Merck
Finite Lived Intangible Assets [Line Items]
Cost of sales - amortization of intangible assets	2,500,000	$ 9,200,000
Symphony Dynamo Holdings Llc | Asset Purchase Agreement
Finite Lived Intangible Assets [Line Items]
Amount paid to third party	$ 2,500,000

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- Definition

Amount paid to third party.

+ References

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- Definition

Contingent milestone payment receivable.

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No definition available.

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- Definition

Upfront payment.

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No definition available.

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Upfront payment receivable.

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- Definition

Amount of expense for allocation of cost of intangible asset over its useful life directly used in production of good and rendering of service.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(b)(2))
-URI http://asc.fasb.org/extlink&oid=120395209&loc=SL114868664-224227

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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- Definition

Amount of gain (loss) from the difference between the sale price or salvage price and the book value of an asset that was sold or retired, and gain (loss) from the write down of assets from their carrying value to fair value.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3602-108585

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- Definition

The amount of impairment loss recognized in the period resulting from the write-down of the carrying amount of a finite-lived intangible asset to fair value.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3602-108585

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 350
-SubTopic 30
-Section 50
-Paragraph 3
-Subparagraph (b)
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The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.4)
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