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Commitments and Contingencies - Additional Information (Detail) € in Millions			1 Months Ended			12 Months Ended
	Sep. 17, 2018 USD ($) ft²	Feb. 20, 2018 USD ($)	Aug. 31, 2020 USD ($)	Jul. 31, 2019 USD ($) ft²	Nov. 30, 2009 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2020 EUR (€)	Dec. 31, 2019 EUR (€)	Mar. 29, 2019 USD ($)	Dec. 31, 2004 EUR (€)
Loss Contingencies [Line Items]
Tenant improvement allowance						$ (1,137,000)	$ (6,999,000)
Sublease income						7,706,000	2,619,000
Cash paid for amounts included in the measurement of operating lease liabilities						6,900,000	5,500,000
Non-cancelable purchase and other commitments						21,700,000
Liability under agreement						294,579,000	270,778,000
Symphony Dynamo Holdings Llc
Loss Contingencies [Line Items]
License arrangement contingent consideration percentage					50.00%
License arrangement upfront payment					$ 50,000,000
Symphony Dynamo Holdings Llc | Asset Purchase Agreement
Loss Contingencies [Line Items]
Liability under agreement						$ 0
Contingent precommencialization milestone payments percentage						50.00%		50.00%
Amount paid to third party			$ 2,500,000
Surety Bond
Loss Contingencies [Line Items]
Guarantee to support license						$ 100,000
Services and Materials
Loss Contingencies [Line Items]
Non-cancelable purchase and other commitments						300,000
Deutsche Bank Securities
Loss Contingencies [Line Items]
Letter of credit pledged as security | €											€ 0.2
Collateralized certificate of deposit | €								€ 0.2	€ 0.2
CRG Servicing LLC
Loss Contingencies [Line Items]
Maximum borrowing capacity		$ 175,000,000.0
Current borrowing capacity		$ 100,000,000.0								$ 75,000,000.0
Contractual obligation						188,100,000
Principal amount						175,000,000.0
Paid-in-kind interest						5,900,000
Backend facility fee						$ 7,200,000
Debt maturity date		Dec. 31, 2023				Dec. 31, 2023
Emeryville, California (Premises) | Horton Street Sublease
Loss Contingencies [Line Items]
Lease area | ft²				75,662
Base rent per square feet				$ 5.50
Lease expiration date				Mar. 31, 2031
Option to extend				The Subtenant has no option to extend the sublease term.
Existence of option to extend				false
Emeryville, California (Premises) | Horton Street Sublease | Other Nonoperating Income (Expense)
Loss Contingencies [Line Items]
Sublease income						$ 7,700,000	$ 2,600,000
Powell Street Sublease | Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area | ft²				23,976
Base rent per square feet				$ 3.90
Lease expiration date				Jun. 30, 2022
Option to extend						There is no option to extend the sublease term.
Existence of option to extend						false
Horton Street Master Lease
Loss Contingencies [Line Items]
Percentage of excess rent paid to landlord						50.00%		50.00%
Horton Street Master Lease | Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area | ft²	75,662
Base rent per square feet	$ 4.75
Operations commencement date	Apr. 01, 2019
Tenant improvement allowance	$ 8,100,000
Initial lease term	12 years
Lease option to extend	The Horton Street Master Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms
Renewal term of lease	5 years
Horton Street Master Lease | Emeryville, California (Premises) | Maximum
Loss Contingencies [Line Items]
Tenant improvement allowance	$ 8,300,000

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