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Common Stock - Additional Information (Detail) - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Aug. 06, 2020
Nov. 03, 2017
Feb. 12, 2021
May 31, 2020
Aug. 31, 2019
Jun. 30, 2020
Dec. 31, 2020
Dec. 31, 2019
Feb. 28, 2021
Mar. 11, 2020
Aug. 12, 2019
Class Of Stock [Line Items]                      
Common stock, shares outstanding             110,189,859 83,871,000      
Issuance of common stock and preferred stock (in shares)         18,525,000            
Common stock, par value         $ 0.001   $ 0.001 $ 0.001      
Preferred stock, par value             $ 0.001 $ 0.001      
Common Stock Shares Sold             8,005,467        
Received Net Cash Proceeds             $ 32,300,000        
Proceeds from issuances of common stock, net             108,538,000 $ 65,948,000      
Preferred stock deemed dividend               3,267,000      
Decrease in estimated fair value of warrant liability upon revaluation             (4,124,000) $ 7,500,000      
Subsequent Event                      
Class Of Stock [Line Items]                      
Number of common stock warrants exercised                 750,000    
Common Stock                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)               19,912,000      
Number of common stock allowed to purchase           700,000          
Warrant Liability                      
Class Of Stock [Line Items]                      
Fair value of derivative liability             10,700,000 $ 14,900,000     $ 7,400,000
Warrant Liability | Other Nonoperating Income (Expense)                      
Class Of Stock [Line Items]                      
Decrease in estimated fair value of warrant liability upon revaluation             $ 4,100,000 $ 7,500,000      
Bain Life Sciences                      
Class Of Stock [Line Items]                      
Net cash proceeds received from issuance or sale of equity         $ 35,000,000.0            
Net cash proceeds received from issuance or sale of equity         $ 35,000,000.0            
Bain Capital Life Sciences Fund, L.P                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)         6,826,266            
Number of common stock allowed to purchase         2,645,566            
Net cash proceeds received from issuance or sale of equity         $ 31,700,000            
Net cash proceeds received from issuance or sale of equity         $ 31,700,000            
BCIP Life Sciences Associates, L.P                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)         698,734            
Number of common stock allowed to purchase         270,684            
Net cash proceeds received from issuance or sale of equity         $ 3,200,000            
Net cash proceeds received from issuance or sale of equity         $ 3,200,000            
Offering                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)       2,100,000              
Common stock, par value       $ 0.001              
Number of common stock allowed to purchase         0.25            
Combined price of common stock and warrant         $ 3.00            
Net cash proceeds received from issuance or sale of equity       $ 75,400,000 $ 65,600,000            
Payment of issuance costs         4,500,000            
Price of common stock       $ 5.00              
Net cash proceeds received from issuance or sale of equity       $ 75,400,000 $ 65,600,000            
Offering | Common Stock                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)             24,215,000        
Offering | Bain Capital Life Sciences Fund, L.P                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)       1,000,000              
2017 ATM Agreement                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)             109,176        
Commission on gross sales proceeds of common stock   3.00%                  
Proceeds from issuances of common stock, net             $ 800,000        
Remaining proceeds from common stock, under sales agreement             $ 149,100,000        
2020 ATM Agreement                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)     2,299,952                
Proceeds from issuances of common stock, net     $ 22,700,000                
Series B Convertible Preferred Stock                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)         4,840 700          
Preferred stock, par value         $ 0.001            
Preferred stock, shares outstanding             4,140 5,000      
Preferred stock deemed dividend             $ 3,300,000        
Series B Convertible Preferred Stock | Common Stock                      
Class Of Stock [Line Items]                      
Number of common stock allowed to purchase               1,000      
Series B Convertible Preferred Stock | Bain Capital Life Sciences Fund, L.P                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)         3,756            
Series B Convertible Preferred Stock | BCIP Life Sciences Associates, L.P                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)         384            
Series B Convertible Preferred Stock | Offering                      
Class Of Stock [Line Items]                      
Number of common stock allowed to purchase         250            
Combined price of preferred stock and warrant         $ 3,000            
Series C Convertible Preferred Stock | Bain Life Sciences | Common Stock                      
Class Of Stock [Line Items]                      
Number of common stock allowed to purchase                   1,000  
Conversion price per share                   $ 4.50  
Maximum                      
Class Of Stock [Line Items]                      
Common stock sales agreement aggregate sales proceeds $ 150,000,000                    
Maximum | Warrant Liability                      
Class Of Stock [Line Items]                      
Percentage of common stock held not to exceed for warrant exercises               19.99%      
Maximum | Offering                      
Class Of Stock [Line Items]                      
Issuance of common stock and preferred stock (in shares)       16,100,000              
Warrant issued         5,841,250            
Maximum | 2017 ATM Agreement                      
Class Of Stock [Line Items]                      
Common stock sales agreement aggregate sales proceeds   $ 150,000,000                  
Maximum | Series B Convertible Preferred Stock                      
Class Of Stock [Line Items]                      
Percentage of common stock held not to exceed for warrant exercises             19.99%        
Minimum | Warrant Liability                      
Class Of Stock [Line Items]                      
Percentage of common stock to be held for exercise of warrants               4.99%      
Minimum | Series B Convertible Preferred Stock                      
Class Of Stock [Line Items]                      
Percentage of common stock to be held for conversion             4.99%