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Common Stock, Preferred Stock and Warrants - Additional Information (Detail) - USD ($)
 1 Months Ended 3 Months Ended
Aug. 06, 2020
Nov. 03, 2017
May 31, 2020
Aug. 31, 2019
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2020
Mar. 11, 2020
Aug. 12, 2019
Class Of Stock [Line Items]                  
Common stock, shares outstanding         114,563,212   110,190,000    
Issuance of common stock and preferred stock (in shares)       18,525,000          
Common stock, par value       $ 0.001 $ 0.001   $ 0.001    
Preferred stock, par value         $ 0.001   $ 0.001    
Net cash proceeds received         $ 28,156,000 $ 14,229,000      
Change in fair value of warrant liability         $ 25,552,000 $ (8,610,000)      
Common Stock                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)         2,879,000 2,909,000      
Number of common stock allowed to purchase               1,000  
Conversion price per share               $ 4.50  
Warrants                  
Class Of Stock [Line Items]                  
Fair value of derivative liability         $ 31,700,000       $ 7,400,000
Warrants | Other Income, Net                  
Class Of Stock [Line Items]                  
Change in fair value of warrant liability         $ 25,600,000        
Bain Life Sciences                  
Class Of Stock [Line Items]                  
Net cash proceeds received from issuance or sale of equity       $ 35,000,000.0          
Bain Capital Life Sciences Fund, L.P                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)       6,826,266          
Number of common stock allowed to purchase       2,645,566          
Net cash proceeds received from issuance or sale of equity       $ 31,700,000          
BCIP Life Sciences Associates, L.P                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)       698,734          
Number of common stock allowed to purchase       270,684          
Net cash proceeds received from issuance or sale of equity       $ 3,200,000          
Offering                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)     2,100,000            
Common stock, par value     $ 0.001            
Number of common stock allowed to purchase       0.25          
Combined price of common stock and warrant       $ 3.00          
Net cash proceeds received from issuance or sale of equity     $ 75,400,000 $ 65,600,000          
Payment of issuance costs       $ 4,500,000          
Price of common stock     $ 5.00            
Offering | Bain Capital Life Sciences Fund, L.P                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)     1,000,000            
2017 ATM Agreement                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)         2,878,567        
Net cash proceeds received         $ 28,200,000        
Remaining proceeds from common stock, under sales agreement         $ 120,500,000        
Series B Convertible Preferred Stock                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)       4,840          
Preferred stock, par value       $ 0.001          
Preferred stock, shares outstanding         4,140   4,000    
Preferred stock deemed dividend         $ 3,300,000        
Series B Convertible Preferred Stock | Common Stock                  
Class Of Stock [Line Items]                  
Number of common stock allowed to purchase         1,000        
Series B Convertible Preferred Stock | Bain Capital Life Sciences Fund, L.P                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)       3,756          
Series B Convertible Preferred Stock | BCIP Life Sciences Associates, L.P                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)       384          
Series B Convertible Preferred Stock | Offering                  
Class Of Stock [Line Items]                  
Number of common stock allowed to purchase       250          
Combined price of preferred stock and warrant       $ 3,000          
Maximum                  
Class Of Stock [Line Items]                  
Common stock sales agreement aggregate sales proceeds $ 150,000,000                
Maximum | Warrants                  
Class Of Stock [Line Items]                  
Percentage of common stock held not to exceed for warrant exercises         19.99%        
Maximum | Offering                  
Class Of Stock [Line Items]                  
Issuance of common stock and preferred stock (in shares)     16,100,000            
Warrant issued       5,841,250          
Maximum | 2017 ATM Agreement                  
Class Of Stock [Line Items]                  
Common stock sales agreement aggregate sales proceeds   $ 150,000,000              
Commission on gross sales proceeds of common stock   3.00%              
Maximum | Series B Convertible Preferred Stock                  
Class Of Stock [Line Items]                  
Percentage of common stock held not to exceed for warrant exercises         19.99%        
Minimum | Warrants                  
Class Of Stock [Line Items]                  
Percentage of common stock to be held for exercise of warrants         4.99%        
Minimum | Series B Convertible Preferred Stock                  
Class Of Stock [Line Items]                  
Percentage of common stock to be held for conversion         4.99%