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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Preferred Stock
Additional Paid-in Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2019 $ 8,290 $ 84   $ 1,229,417 $ (2,387) $ (1,218,824)
Beginning Balances (in shares) at Dec. 31, 2019   83,871 5      
Issuance of common stock upon exercise of stock options and restricted stock awards, net (1) $ 1   (2)    
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)   728        
Issuance of common stock under Employee Stock Purchase Plan 311     311    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   91        
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 14,229 $ 3   14,226    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   2,909        
Stock compensation expense 1,778     1,778    
Total other comprehensive income (Loss) (188)       (188)  
Net income (loss) (12,595)         (12,595)
Ending Balances at Mar. 31, 2020 11,824 $ 88   1,245,730 (2,575) (1,231,419)
Ending Balances (in shares) at Mar. 31, 2020   87,599 5      
Beginning Balances at Dec. 31, 2020 58,693 $ 110   1,352,374 273 (1,294,064)
Beginning Balances (in shares) at Dec. 31, 2020   110,190 4      
Exercise of warrants 7,928 $ 1   7,927    
Stock Issued Exercise of Warrants During Period, Shares, New Issues   750        
Issuance of common stock upon exercise of stock options and restricted stock awards, net 387     387    
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)   640        
Issuance of common stock under Employee Stock Purchase Plan 383     383    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   104        
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement 28,156 $ 3   28,153    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   2,879        
Stock compensation expense 4,723     4,723    
Total other comprehensive income (Loss) (1,399)       (1,399)  
Net income (loss) 891         891
Ending Balances at Mar. 31, 2021 $ 99,762 $ 114   $ 1,393,947 $ (1,126) $ (1,293,173)
Ending Balances (in shares) at Mar. 31, 2021   114,563 4