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Commitments and Contingencies - Additional Information (Detail) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Sep. 17, 2018 USD ($) ft² | Aug. 31, 2020 USD ($) | Jul. 31, 2019 USD ($) ft² | Nov. 30, 2009 USD ($) | Jun. 30, 2021 USD ($) | Jun. 30, 2020 USD ($) | Jun. 30, 2021 USD ($) | Jun. 30, 2020 USD ($) | Jun. 30, 2021 EUR (€) | May 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2004 EUR (€)
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Tenant improvement allowance |  |  |  |  |  |  |  | $ (908,000) |  |  |  |
Sublease income |  |  |  |  | $ 1,670,000 | $ 1,927,000 | $ 3,692,000 | 3,853,000 |  |  |  |
Cash paid for amounts included in the measurement of operating lease liabilities |  |  |  |  |  |  | 3,400,000 | 3,400,000 |  |  |  |
Non-cancelable purchase and other commitments |  |  |  |  | 106,800,000 |  | 106,800,000 |  |  |  |  |
Aggregate principal amount |  |  |  |  | 225,500,000 |  | $ 225,500,000 |  |  |  |  |
Long-term debt, net of debt discount |  |  |  |  |  |  |  |  |  |  | $ 1,094,000 |
Debt maturity date |  |  |  |  |  |  | May 15, 2026 |  |  |  |  |
Letter of credit pledged as security | € |  |  |  |  |  |  |  |  |  |  |  | € 200,000
Collateralized certificate of deposit | € |  |  |  |  |  |  |  |  | € 200,000 |  |  |
Payment to holdings |  | $ 2,500,000 |  |  |  |  |  |  |  |  |  |
Liability under agreement |  |  |  |  | 564,529,000 |  | $ 564,529,000 |  |  |  | $ 294,579,000 |
Symphony Dynamo Holdings LLC |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
License arrangement contingent consideration percentage |  |  |  | 50.00% |  |  |  |  |  |  |  |
License arrangement upfront payment |  |  |  | $ 50,000,000 |  |  |  |  |  |  |  |
Symphony Dynamo Holdings LLC | Asset Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Liability under agreement |  |  |  |  | $ 0 |  | $ 0 |  |  |  |  |
Contingent pre-commercialization milestone payments percentage |  |  |  |  | 50.00% |  | 50.00% |  | 50.00% |  |  |
2.50% Convertible Senior Notes Due 2026 |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  | $ 225,500,000 |  | $ 225,500,000 |  |  | $ 200,000,000.0 |  |
Long-term debt, net of debt discount |  |  |  |  | $ 5,500,000 |  | $ 5,500,000 |  |  |  |  |
Debt maturity date |  |  |  |  |  |  | May 15, 2026 |  |  |  |  |
Powell Street Sublease | Emeryville, California (Premises) |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Lease area | ft² |  |  | 23,976 |  |  |  |  |  |  |  |  |
Base rent per square feet |  |  | $ 3.90 |  |  |  |  |  |  |  |  |
Lease expiration date |  |  | Jun. 30, 2022 |  |  |  |  |  |  |  |  |
Option to extend |  |  |  |  |  |  | There is no option to extend the sublease term |  |  |  |  |
Existence of option to extend |  |  |  |  |  |  | false |  |  |  |  |
Horton Street Master Lease |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Percentage of excess rent paid to landlord |  |  |  |  | 50.00% |  | 50.00% |  | 50.00% |  |  |
Horton Street Master Lease | Emeryville, California (Premises) |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Lease area | ft² | 75,662 |  |  |  |  |  |  |  |  |  |  |
Base rent per square feet | $ 4.75 |  |  |  |  |  |  |  |  |  |  |
Operations commencement date | Apr. 01, 2019 |  |  |  |  |  |  |  |  |  |  |
Tenant improvement allowance | $ 8,100,000 |  |  |  |  |  |  |  |  |  |  |
Initial lease term | 12 years |  |  |  |  |  |  |  |  |  |  |
Lease option to extend | The Horton Street Master Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms. |  |  |  |  |  |  |  |  |  |  |
Renewal term of lease | 5 years |  |  |  |  |  |  |  |  |  |  |
Horton Street Sublease | Emeryville, California (Premises) |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Lease area | ft² |  |  | 75,662 |  |  |  |  |  |  |  |  |
Base rent per square feet |  |  | $ 5.50 |  |  |  |  |  |  |  |  |
Lease expiration date |  |  | Mar. 31, 2031 |  |  |  |  |  |  |  |  |
Option to extend |  |  | The Subtenant has no option to extend the sublease term. |  |  |  |  |  |  |  |  |
Existence of option to extend |  |  | false |  |  |  |  |  |  |  |  |
Horton Street Sublease | Emeryville, California (Premises) | Other Income (Expense) |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Sublease income |  |  |  |  | $ 1,700,000 | $ 1,900,000 | $ 3,700,000 | $ 3,900,000 |  |  |  |

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