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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 6 Months Ended |
--- | --- | --- | --- | ---
May 31, 2021 USD ($) | Jun. 30, 2021 USD ($) | Jun. 30, 2020 USD ($) | Jun. 30, 2021 USD ($) Segment | Jun. 30, 2020 USD ($) | Dec. 31, 2020 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Number of operating segment | Segment |  |  |  | 1 |  |
Cash, cash equivalents and marketable securities |  | $ 345,800,000 |  | $ 345,800,000 |  |
Aggregate principal amount |  | 225,500,000 |  | $ 225,500,000 |  |
Long-term debt, net of debt discount |  |  |  |  |  | $ 1,094,000
Debt maturity date |  |  |  | May 15, 2026 |  |
Net income (loss) |  | 4,473,000 | $ (51,579,000) | $ 5,364,000 | $ (64,174,000) |
Inventory reserve |  | 0 | $ 0 | $ 0 | $ 0 |
Maximum |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Expected period of payment to be received |  |  |  | 1 year |  |
2.50% Convertible Senior Notes Due 2026 |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Aggregate principal amount | $ 200,000,000.0 | $ 225,500,000 |  | $ 225,500,000 |  |
Debt interest rate | 2.50% | 2.50% |  | 2.50% |  |
Long-term debt, net of debt discount |  | $ 5,500,000 |  | $ 5,500,000 |  |
Debt maturity date |  |  |  | May 15, 2026 |  |
Loan Agreement |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Repayments of debt | $ 190,200,000 |  |  | $ 190,200,000 |  |
Capped Calls |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Net Proceeds to Pay the Costs | $ 27,200,000 |  |  | $ 27,200,000 |  |
HEPLISAV-B |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Minimum age approved for vaccine prevention of infection caused |  |  |  | 18 years |  |

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