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Condensed Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands | Total | Common Stock | Preferred Stock | Additional Paid-in Capital | Accumulated Other Comprehensive (Loss) Income | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Beginning Balances at Dec. 31, 2019 | $ 8,290 | $ 84 |  | $ 1,229,417 | $ (2,387) | $ (1,218,824)
Beginning Balances (in shares) at Dec. 31, 2019 |  | 83,871 | 5 |  |  |
Conversion of preferred stock | 1 | $ 1 |  |  |  |
Conversion of preferred stock, shares |  | 700 |  |  |  |
Conversion of preferred stock, shares |  |  | (1) |  |  |
Issuance of common stock upon exercise of stock options and restricted stock awards, net | 13 | $ 1 |  | 12 |  |
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares) |  | 735 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 311 |  |  | 311 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 91 |  |  |  |
Issuance of common stock, net of issuance costs, in conjunction with an underwritten public offering and an At Market Sales Agreement | 107,696 | $ 23 |  | 107,673 |  |
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares) |  | 24,106 |  |  |  |
Stock compensation expense | 5,866 |  |  | 5,866 |  |
Total other comprehensive income (Loss) | 292 |  |  |  | 292 |
Net income (loss) | (64,174) |  |  |  |  | (64,174)
Ending Balances at Jun. 30, 2020 | 58,295 | $ 109 |  | 1,343,279 | (2,095) | (1,282,998)
Ending Balances (in shares) at Jun. 30, 2020 |  | 109,503 | 4 |  |  |
Beginning Balances at Mar. 31, 2020 | 11,824 | $ 88 |  | 1,245,730 | (2,575) | (1,231,419)
Beginning Balances (in shares) at Mar. 31, 2020 |  | 87,599 | 5 |  |  |
Conversion of preferred stock | 1 | $ 1 |  |  |  |
Conversion of preferred stock, shares |  | 700 |  |  |  |
Conversion of preferred stock, shares |  |  | (1) |  |  |
Issuance of common stock upon exercise of stock options and restricted stock awards, net | 14 |  |  | 14 |  |
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares) |  | 7 |  |  |  |
Issuance of common stock, net of issuance costs, in conjunction with an underwritten public offering and an At Market Sales Agreement | 93,467 | $ 20 |  | 93,447 |  |
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares) |  | 21,197 |  |  |  |
Stock compensation expense | 4,088 |  |  | 4,088 |  |
Total other comprehensive income (Loss) | 480 |  |  |  | 480 |
Net income (loss) | (51,579) |  |  |  |  | (51,579)
Ending Balances at Jun. 30, 2020 | 58,295 | $ 109 |  | 1,343,279 | (2,095) | (1,282,998)
Ending Balances (in shares) at Jun. 30, 2020 |  | 109,503 | 4 |  |  |
Beginning Balances at Dec. 31, 2020 | 58,693 | $ 110 |  | 1,352,374 | 273 | (1,294,064)
Beginning Balances (in shares) at Dec. 31, 2020 |  | 110,190 | 4 |  |  |
Exercise of warrants | 7,928 | $ 1 |  | 7,927 |  |
Exercise of warrants, shares |  | 750 |  |  |  |
Issuance of common stock upon exercise of stock options and restricted stock awards, net | 1,335 |  |  | 1,335 |  |
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares) |  | 833 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 383 |  |  | 383 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 104 |  |  |  |
Issuance of common stock, net of issuance costs, in conjunction with an underwritten public offering and an At Market Sales Agreement | 28,156 | $ 3 |  | 28,153 |  |
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares) |  | 2,879 |  |  |  |
Purchase of capped call options related to issuance of Convertible Notes | (27,240) |  |  | (27,240) |  |
Stock compensation expense | 9,747 |  |  | 9,747 |  |
Total other comprehensive income (Loss) | (986) |  |  |  | (986) |
Net income (loss) | 5,364 |  |  |  |  | 5,364
Ending Balances at Jun. 30, 2021 | 83,380 | $ 114 |  | 1,372,679 | (713) | (1,288,700)
Ending Balances (in shares) at Jun. 30, 2021 |  | 114,756 | 4 |  |  |
Beginning Balances at Mar. 31, 2021 | 99,762 | $ 114 |  | 1,393,947 | (1,126) | (1,293,173)
Beginning Balances (in shares) at Mar. 31, 2021 |  | 114,563 | 4 |  |  |
Issuance of common stock upon exercise of stock options and restricted stock awards, net | 948 |  |  | 948 |  |
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares) |  | 193 |  |  |  |
Purchase of capped call options related to issuance of Convertible Notes | (27,240) |  |  | (27,240) |  |
Stock compensation expense | 5,024 |  |  | 5,024 |  |
Total other comprehensive income (Loss) | 413 |  |  |  | 413 |
Net income (loss) | 4,473 |  |  |  |  | 4,473
Ending Balances at Jun. 30, 2021 | $ 83,380 | $ 114 |  | $ 1,372,679 | $ (713) | $ (1,288,700)
Ending Balances (in shares) at Jun. 30, 2021 |  | 114,756 | 4 |  |  |

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