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Commitments and Contingencies - Additional Information (Detail)		1 Months Ended			3 Months Ended		6 Months Ended
	Sep. 17, 2018 USD ($) ft²	Aug. 31, 2020 USD ($)	Jul. 31, 2019 USD ($) ft²	Nov. 30, 2009 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2020 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2020 USD ($)	Jun. 30, 2021 EUR (€)	May 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2004 EUR (€)
Loss Contingencies [Line Items]
Tenant improvement allowance								$ (908,000)
Sublease income					$ 1,670,000	$ 1,927,000	$ 3,692,000	3,853,000
Cash paid for amounts included in the measurement of operating lease liabilities							3,400,000	3,400,000
Non-cancelable purchase and other commitments					106,800,000		106,800,000
Aggregate principal amount					225,500,000		$ 225,500,000
Long-term debt, net of debt discount											$ 1,094,000
Debt maturity date							May 15, 2026
Letter of credit pledged as security \| €												€ 200,000
Collateralized certificate of deposit \| €									€ 200,000
Payment to holdings		$ 2,500,000
Liability under agreement					564,529,000		$ 564,529,000				$ 294,579,000
Symphony Dynamo Holdings LLC
Loss Contingencies [Line Items]
License arrangement contingent consideration percentage				50.00%
License arrangement upfront payment				$ 50,000,000
Symphony Dynamo Holdings LLC \| Asset Purchase Agreement
Loss Contingencies [Line Items]
Liability under agreement					$ 0		$ 0
Contingent pre-commercialization milestone payments percentage					50.00%		50.00%		50.00%
2.50% Convertible Senior Notes Due 2026
Loss Contingencies [Line Items]
Aggregate principal amount					$ 225,500,000		$ 225,500,000			$ 200,000,000.0
Long-term debt, net of debt discount					$ 5,500,000		$ 5,500,000
Debt maturity date							May 15, 2026
Powell Street Sublease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²			23,976
Base rent per square feet			$ 3.90
Lease expiration date			Jun. 30, 2022
Option to extend							There is no option to extend the sublease term
Existence of option to extend							false
Horton Street Master Lease
Loss Contingencies [Line Items]
Percentage of excess rent paid to landlord					50.00%		50.00%		50.00%
Horton Street Master Lease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²	75,662
Base rent per square feet	$ 4.75
Operations commencement date	Apr. 01, 2019
Tenant improvement allowance	$ 8,100,000
Initial lease term	12 years
Lease option to extend	The Horton Street Master Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms.
Renewal term of lease	5 years
Horton Street Sublease \| Emeryville, California (Premises)
Loss Contingencies [Line Items]
Lease area \| ft²			75,662
Base rent per square feet			$ 5.50
Lease expiration date			Mar. 31, 2031
Option to extend			The Subtenant has no option to extend the sublease term.
Existence of option to extend			false
Horton Street Sublease \| Emeryville, California (Premises) \| Other Income (Expense)
Loss Contingencies [Line Items]
Sublease income					$ 1,700,000	$ 1,900,000	$ 3,700,000	$ 3,900,000